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Clinical school: Rheumatology > Autoantibodies > Flashcards

Flashcards in Autoantibodies Deck (35)
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1

What is rheumatoid factor (RhF) associated with?

- Sjogren's syndrome (≤100%)

- Felty's syndrome (≤100%)

- Rheumatoid arthritis (70%)

- Mixed connective tissue disease (50%)

- SLE (≤40%)

- Systemic sclerosis (30%)

- Normal (2-10%)

2

What is anticyclic citrullinated peptide Ab (anti-CCP) associated with?

Rheumatoid arthritis (96% specificity)

 

3

What is antinuclear antibody (ANA) associated with?

- SLE (>95%)

- Type I autoimmune hepatitis (75%)

- Sjogren's syndrome (68%)

- Systemic sclerosis (96%)

- Rheumatoid arthritis (30%)

- Normal (0-2%)

4

What is associated with homogeneous immunofluorescence staining of ANA? 

SLE

5

What is associated with speckled immunofluorescence staining of ANA

Mixed connective tissue disease

6

What is associated with nucleolar immunofluorescence staining of ANA?

Systemic sclerosis

 

7

What is associated with centromere immunofluorescence staining of ANA?

Limited systemic sclerosis

8

What is associated with anti-double-stranded DNA (dsDNA) antibodies?

SLE (60% sensitivity, but very high specificity)

9

What is associated with antihistone antibodies?

Drug-induced SLE (~100%)

10

What are anti-phospholipid antibodies?

  • Lupus anticoagulant [LA]
  • Anticardiolipin [aCL] antibodies
  • Anti-β2-glycoprotein antibodies

11

What is associated with anti-phospholipid antibodies?

- Anti-phospholipid syndrome

- SLE

12

What is associated with anti-centromere antibodies?

Limited systemic sclerosis

13

What is associated with anti-Ro antibodies?

- SLE

- Sjogren's syndrome

- Systemic sclerosis

14

What is associated with anti-Sm antibodies?

SLE (20-30%)

15

What is associated with anti-RNP antibodies?

- SLE

- Mixed connective tissue disease

16

What is associated with anti-Jo-1 and anti-Mi-2 antibodies?

- Polymyositis

- Dermatomyositis

17

What is associated with anti-Scl70 antibodies?

Diffuse systemic sclerosis

18

What is associated with anti-mitochondrial antibodies (AMA)?

- Primary biliary cholangitis (>95%)

- Autoimmune hepatitis (30%)

- Idiopathic cirrhosis (25-30%)

19

What is associated with anti-smooth muscle antibodies (ASMA)?

- Type I autoimmune hepatitis (70%)

- Primary biliary cholangitis (50%)

- Idiopathic cirrhosis (25-30%)

20

What is associated with anti-gastric parietal cell antibodies?

- Pernicious anaemia (>90%)

- Atrophic gastritis (40%)

- Normal (10%)

21

What is associated with anti-intrinsic antibodies?

Pernicious anaemia (50%)

22

Which autoantibodies are associated with coeliac disease?

- Anti-alpha-gliadin antibodies

- Anti-tissue transglutaminase antibodies

- Anti-endomysial antibodies

23

What is associated with anti-thyroid peroxidase antibodies?

- Hashimoto's thyroiditis (~87%)

- Grave's disease (>50%)

 

24

Which autoantibodies are associated with type I diabetes mellitus?

- Anti-islet cell antibodies (ICA)

- Anti-glutamic acid decarboxylase (GAD) antibodies

 

25

What is associated with anti-GBM antibodies?

Goodpasture's syndrome

26

What is associated with cANCA (specific for serine protease-3, PR3)?

- Granulomatosis with polyangiitis (Wegener's syndrome) (90%)

- Micorscopic polyangiitis (30%)

- Polyarteritis nodosa (11%)

27

What is associated with pANCA (specific for myeloperoxidase, MPO)?

- Mocroscopic polyangiitis (~45%)

- Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

- Goodpasture's syndrome

28

Aside from vasculitides, which other extra-vascular conditions may be +ve for ANCA (predominantly p-ANCA)?

- IBD

- Primary sclerosing cirrhosis

- Autoimmune hepatitis

- Felty's syndome

- Rheumatoid arthritis

- SLE

- Drugs (e.g. anti-thyroid, allopurinol, cprofloxacin)

29

What is associated with anti-AChR antibodies?

Myasthenia gravis

30

What is associated with anti-voltage gated potassium channel antibodies?

Limbic encephalitis