Flashcards in Autoimmune Dx - Systemic Lupus Erythematosus (SLE) Deck (26):
What's the hallmark of SLE?
Development of auto-antibodies by B cells to cellular components that leads to chronic inflammation and tissue damage
What's the most common SE of SLE?
Butterfly rash (xteristic red, flat facial rash over bridge of nose and cheeks)
What's the most common manifestations of SLE?
Arthritis and cutaneous manifestations
What manifestations contribute largely to morbidity and mortality?
What develops in over 50% of pts with SLE?
List primary agents ass with drug-induced lupus?
Hydralazine (alone and in BiDil)
List non-pharmacologic therapy for lupus
Smoking cessation (if applicable)
Sunscreen or avoiding sun (photosensitivity)
What's the goal of SLE therapy?
Suppress immune system to avoid flare and keep pt in remission
What's the tx method for SLE?
Combo of drugs to minimize chronic exposure to corticosteroids
List antimalarial agents used in lupus
MOA of antimalarial agents
Impair complement-dependent antigen-antibody rxn
Which antimalarial is preferred (safer)?
How long does it take to see maximal effect of hydroxychloroquine in SLE?
What's hydroxychloroquine used for?
Mild dx; chronic (not acute) therapy
Effective for cutaneous sx and Arthralgias
Which corticosteroids is used as an agent in lupus?
Prednisone OR Methylprednisolone IV
Which cytotoxic agents are used in severe dx of lupus?
Mycophenolate mofetil (CellCept)
What's the brand name of Mycophenolate mofetil?
What's the SE of cyclophosphamide (cytotoxic agent used in severe dx of lupus)?
How do u deal with Hemorrhagic cystitis that results from cyclophosphamide?
Mesna therapy + hydration
Howz cyclophosphamide used in lupus?
For flares as induction therapy
NOT for chronic therapy...very toxic
SE of Mycophenolate (CellCept) use?
Hypo- and hypertension?
Hypo and hyperkalemia
What's the brand name for cyclosporine?
SE of cyclosporine (neoral/ Sandimmune)?
MOA of IgG1-lambda monoclonal antibody?
Prevents the survival of B lymphocytes by blocking the binding of soluble human B lymphocyte stimulator protein (BLyS) to receptors on B lymphocytes
List agents that are IgG1-lambda monoclonal antibody