Autoimmune Dx - Systemic Lupus Erythematosus (SLE) Flashcards Preview

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Flashcards in Autoimmune Dx - Systemic Lupus Erythematosus (SLE) Deck (26):
0

What's the hallmark of SLE?

Development of auto-antibodies by B cells to cellular components that leads to chronic inflammation and tissue damage

1

What's the most common SE of SLE?

Butterfly rash (xteristic red, flat facial rash over bridge of nose and cheeks)

2

What's the most common manifestations of SLE?

Arthritis and cutaneous manifestations

3

What manifestations contribute largely to morbidity and mortality?

Renal

Hematologic

Neurologic

4

What develops in over 50% of pts with SLE?

Lupus nephritis

5

List primary agents ass with drug-induced lupus?

Procainamide

Hydralazine (alone and in BiDil)

Isoniazid

Methyldopa

Propylthiouracil

Methimazole

Terbinafine

Anti-TNF agents

6

List non-pharmacologic therapy for lupus

Rest

Proper exercise

Smoking cessation (if applicable)

Sunscreen or avoiding sun (photosensitivity)

7

What's the goal of SLE therapy?

Suppress immune system to avoid flare and keep pt in remission

8

What's the tx method for SLE?

Combo of drugs to minimize chronic exposure to corticosteroids

9

List antimalarial agents used in lupus

Hydroxychloroquine

Chloroquine

10

MOA of antimalarial agents

Impair complement-dependent antigen-antibody rxn

11

Which antimalarial is preferred (safer)?

Hydroxychloroquine

12

How long does it take to see maximal effect of hydroxychloroquine in SLE?

6 months

13

What's hydroxychloroquine used for?

Mild dx; chronic (not acute) therapy

Effective for cutaneous sx and Arthralgias

14

Which corticosteroids is used as an agent in lupus?

Prednisone OR Methylprednisolone IV

15

Which cytotoxic agents are used in severe dx of lupus?

Cyclophosphamide

Azathioprine

Mycophenolate mofetil (CellCept)

Cyclosporine

16

What's the brand name of Mycophenolate mofetil?

CellCept

17

What's the SE of cyclophosphamide (cytotoxic agent used in severe dx of lupus)?

Hemorrhagic cystitis

18

How do u deal with Hemorrhagic cystitis that results from cyclophosphamide?

Mesna therapy + hydration

19

Howz cyclophosphamide used in lupus?

For flares as induction therapy

NOT for chronic therapy...very toxic

20

SE of Mycophenolate (CellCept) use?

Diarrhea

GI upset

Vomiting

Hypo- and hypertension?

Edema

Tachycardia

Pain

Hyperglycemia

Hypo and hyperkalemia

Hypomagnesemia; calcemia

Hypercholesterolemia

Tremor

Acne

Infections

21

What's the brand name for cyclosporine?

Neoral/ Sandimmune

22

SE of cyclosporine (neoral/ Sandimmune)?

Hypertension

Nephropathy

23

MOA of IgG1-lambda monoclonal antibody?

Prevents the survival of B lymphocytes by blocking the binding of soluble human B lymphocyte stimulator protein (BLyS) to receptors on B lymphocytes

24

List agents that are IgG1-lambda monoclonal antibody

Belimumab (Benlysta)

25

What's the brand name of Belimumab?

Benlysta

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