autonomic drugs Flashcards Preview

UWorld > autonomic drugs > Flashcards

Flashcards in autonomic drugs Deck (23):
1

pilocarpine

MOA: cholinomimetic (muscarinic agonist)
USE: glaucoma, stimulates sweat/tears/saliva

2

methacholine

MOA: cholinomimetic in airway (bronchoconstrict)
USE: challenge test for asthma diagnosis

3

bethanechol

MOA: cholinomimetic (muscarinic agonist)
USE: urinary retention, ileus

4

neostigmine

MOA: indirect muscarinic agonist - AChE inhibitor
USE: myasthenia gravis, ileus, urinary retention, reversal of postoperative NMJ block

5

physostigmine

MOA: indirect muscarinic agonist - AChE inhibitor
**CNS
USE: anticholinergic toxicity (ie: atropine overdose)

6

edrophonium

MOA: indirect muscarinic agonist - AChE inhibitor
USE: dx of myasthenia gravis (short-actint)

7

donepezil

MOA: AChE inhibitor
USE: Alzheimer disease (also rivastigmine)

8

organophosphates

MOA: irreversible AChE inhibitor
ANTIDOTE: atropine and pralidoxime (AChE regenerator)

9

SLUDGE

too much muscarinic/parasympathetic stimulation
- salivation
- lacrimation
- urination
- defecation
- GI upset
- emesis

10

atropine

MOA: muscarinic antagonist
USE: to reverse SLUDGE, bradycardia, ophthalmic stuff

11

scopolamine

MOA: muscarinic antagonist

12

NMJ blockers

succinylcholine: depolarizing ACh nicotinic agonist
tubocurarine: NMJ nicotinic antagonist

13

antimuscarinic ADR

mad as a hatter
dry as a bone
red as a beet (blood shunted from organs to periphery/mm.)
hot as a hare
blind as a bat

14

phenylephrine

MOA: alpha 1 (some alpha 2) agonist
USE: hypotension, ocular procedures (mydriatic), rhinitis (decongestant)

15

epinephrine receptors

alpha 1, both betas (depends on dose) agonist

16

norepinephrine receptors

a1, a2, b1 agonist

17

isoproterenol receptors

b1, b2 agonist

18

clonidine

MOA: a2 agonist
USE: some hypertensive emergencies, ADHD

19

alpha-methyldopa

MOA: a2 agonist
USE: HTN in pregnancy

20

dobutamine receptor

mostly b1 agonist

21

prazosin, doxazosin

"-osin"
MOA: a1 antagonist
USE: BPH, HTN

22

phentolamine

MOA: nonselective alpha blocker
USE: pts on MAOIs who eat tyramine foods

23

phenoxybenzamine

MOA: nonselective alpha blocker
USE: pheochromocytoma