Autonomic Pharmacology Flashcards Preview

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Flashcards in Autonomic Pharmacology Deck (35):
1

Location of nicotinic (NN) receptors

PANS and SANS ganglia
Adrenal medulla

2

Location of nicotinic (NM) receptors

skeletal muscle motor end plate

3

location of muscarinic receptors

Organs or tissues innervated by post-ganglionic nerves of PNS and thermoregulatory sweat glands of SNS

4

Location of adrenoceptors

Organs or tissues innervated by post-ganglionic nerves of SANS

5

T/F: Nicotinic (NM) receptors are not exclusively ANS receptors since NM can be present in somatic voluntary muscles

True

6

T/F: Catecholamines have more of a neuronal effect rather than humoral or hormonal

False

7

Potential targets for pharmacologic therapy

Synthesis
Storage
Release
Termination of action
Receptor effects

8

Location of norepinephrine

most adrenoceptors in innervated tissues

9

Location of dopamine

D1 receptors in renal vasculature

10

Neurotransmitter from the adrenal medulla which activates most adrenoceptors whether or not the tissues are innervated

Epinephrine

11

Neurotransmitters located in ENS and AND fibers in GI tract

Serotonin (5-HT)
Purines
Peptides

12

Blocks sodium-dependent membrane choline transporter (CHT)

Hemicholiniums

13

Blocks vesicle-associated transporter (VAT)

Vesamicol

14

Blocks calcium receptors in fusion proteins of the presynaptic membrane

Botolinum toxin (Botox)

15

Major mechanism of Ach termination

Acetylcholinesterase (AchE)

16

Pathway of Ach inactivation utilized by indirect acting cholinomimetics

Acetylcholinesterase

17

Target of M1 receptor

Stomach glands

18

Response of stomach glands to M1

Inc. gastric secretion

19

Target of M2 receptor

SA and AV nodes

20

T/F: Ach drug has a short half-life and has no clinical use

True

21

Clinical use of Bethanechol

Induce peristalsis

22

Treatment for paralytic ileus and urinary retention

Bethanechol

23

Treatment for glaucoma and xerostomia

Pilocarpine

24

Treatment for smoking cessation

Nicotine
Lobeline

25

T/F: Inhibiting few AchE with indirect-acting cholimimetics will produce significant effects

False

26

A simple alcohol drug for myasthenia gravis

Edrophonium

27

T/F: A small dose of edrophonium will cause improvement in myasthenia patients, while the same dose will exacerbate cholinergic crisis

True

28

Clinical use of Physostigmine

Glaucoma
Antidote in atropine overdose

29

Quaternary amine carbamates for ileus, urinary retention, myasthenia, reversal of non-depokarizing NM blockers

Neostigmine
Pyridostigmine

30

Treatment for Alzheimer's disease

Donepezil
Tacrine

31

Indirect-acting cholimimetics with intermediate acting effects

Physostigmine
Neostigmine
Pyridostigmine

32

Clinical use of organophosphates

Insecticides
Nerve gas

33

Due to the "aging" effect, antodite for organophosphate poisoning should be given within how many hours to reversibly break PO4-AchE bond?

24 hours

34

Symptoms of cholinergic excess

Diarrhea
Urination
Miosis
Bronchoconstriction
Bradycardia & hypotension
Excitation (skeletal muscle fasciculation, then paralysis)
Lacrimation
Salivation
Sweating

35

Cholinergic excess management

Atropine, plus pralidoxime