Azole derivatives Flashcards Preview

42 Antifungal drugs > Azole derivatives > Flashcards

Flashcards in Azole derivatives Deck (23):
1

Azole derivatives (2 groups)

Diazole compounds
Triazole compounds

2

Diazole compounds (3 drugs)

Clotrimazole
Econazole
Ketoconazole

3

Triazole compounds (4 drugs)

Fluconazole
Itraconazole
Posaconazole
Voriconazole

4

Azole derivatives that can be adm IV (2 drugs)

Fluconazole
Voriconazole

5

Azole drugs that cannot be used with drugs that decrease gastric acid (3 drugs)

Ketoconazole
Itraconazole
Posaconazole

6

Only azole drug used for fungal meningitis

Fluconazole (both prophylaxis and treatment)

7

Azole drugs - adverse effects

Birth defects
Systemic adm: Hepatic injury, hematopoietic toxicity

8

Azole drugs - interactions

Inhibits metabolism of:
HMG-CoA reductase inhibitors
Some benzodiazepines
Quinidine
Warfarin

9

Azole drugs - contraindications

Pregnancy (Cat D for longterm, high doses. Cat C for short term, vaginal)

10

Itraconazole - indications

Systemic mycoses: Blastomycosis, histoplasmosis.
Superficial mycoses: onychomycosis (nails)

11

Itraconazole - amdinistration

Orally in pulse dosing

12

Fluconazole - indications

Cryptococcal meningitis in AIDS
Mucocutaneous and disseminated candidiasis
UTI by candida

13

Azole drug for single dose adm for acute vaginal candidiasis (1 drug)

Fluconazole

14

Second generation triazoles (2 drugs)

Voriconazole
Posaconazole

15

Voriconazole - indications

Invasive aspergillosis
Esophageal candidiasis
Invasive candidiasis

16

Voriconazole - interactions

Additive activity with caspofungin (used for treatment of invasive aspergillosis)

17

Voriconazole - adverse effects

Visual disturbances (altered light perception, chromatopsia, photophobia).
Increased liver enzymes, liver failure (with death sometimes)

18

Posaconazole - indications

Systemic infections not responding to other agents (aspergillus, fusarium, rhizopus, mucormycosis)

19

Which azole drug has higher incidence of drug interactions

Ketoconazole

20

Ketoconazole - indications and adm

Adm topical for seborrheic dermatitis

21

Clotrimazole and econazole - indications

Candida (mouth, throat, vagina, vulva)
Tinea versicolor
Tinea pedis, tinea cruris

22

Clotrimazole and econazole (+other topicals) are not effective for...

Tinea capitis
Tinea unguium/onychomycosis

23

Azole drugs - MOA

Inhibits 14α-demethylase, and conversion of lanosterol to ergosterol