B&B: Herpes Viruses Flashcards Preview

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Flashcards in B&B: Herpes Viruses Deck (18)
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1
Q

All Herpes viruses are

A
enveloped
ds DNA
linear
Icosahedral
Large
Take envelope from nucleus itself (not cell membrane)
2
Q

4 Herpes viruses lead to giant cell formation

A
HSV1
HSV2
VZV
CMV
Visible in Tzanck Smear
3
Q

HSV-1

A

Oral herpes, Herpetic Whitlow, Keratoconjunctivitus, Encephalitis (temporal lobes)

4
Q

HSV-2

A

Oral herpes, genital herpes, meningitis

Latent in lumbar-sacral ganglia

5
Q

HSV-1, HSV-2, VZV Tx

A

acyclovir
valacyclovir
famciclovir

6
Q

HSV-2 Tx

A

Supressive with acyclovir

7
Q

HSV-1, HSV-2, VZV histo

A

Intranuclear inclusions

Cowdry A inclusions

8
Q

EBV causes mono by infecting

A

B cells

9
Q

EBV

A

Envelope glycoprotein gp350/220 binds B-cell receptor CD 21
CD21 is receptor for C3d fragment of complement
CD21 is also called C3d receptor, EBV receptor and CR2

10
Q

EBV mono histo

A

Atypical lymphocyte: CD8+ T cells

11
Q

CMV histo

A

Owl’s Eye nuclei

12
Q

CMV can be latent in

A

monocytes/marrow cells

13
Q

CMV Tx

A

Ganciclovir, Foscarnet, Cidofovir

14
Q

Congenital CMV Tx

A

TORCH infection
Ganciclovir
Valganciclovir

15
Q

HHV-6 causes

A

roseola infantum (sixth disease)

16
Q

HHV-6

A

Starts with febrile phase

Then fever breaks and maculopapular rash that starts in neck and trunk, spreads to face and limbs

17
Q

HHV-6 Tx

A

Self-limiting: No Tx

18
Q

HHV-8 causes

A

Kaposi’s Sarcoma