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Flashcards in B cell Deck (260)
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1

B cells are part of what type of immunity

adaptive immunity

2

adaptive immunity is part of what lineage

lymphoid lineage

3

B cell and T cells recognize

antigens

4

what is an antigen

any molecule or part of a molecule from bacteria, viruses or other diseases causing pathogens that is specifically recognized by highly specialized lymphocyte recognition proteins

5

what are the highly specialized lymphocyte recognition proteins

T and B cells

6

B cells produce

immunoglobulins

7

what is a BCR

membrane bound B-cell receptor

8

what is the shape antibodies make

Y shape

9

antibodies are what type of proteins

glycoproteins

10

antibodies are composed of how many polypeptide chains

4

11

what are the 4 polypeptide chains called in antibodies

heavy and light chains

12

how many amino acids are in one segment of an antibody

roughly 110

13

what is the bond that attaches the arms to the stem of the antibody

disulfide bond

14

arms of the AB are what region

variable

15

stem of AB is what region

constant

16

function of variable region

interact with specific antigen and vary in sequence

17

function of constant region

interacts with effector molecules and cells and more constant in sequence

18

what are the two isotypes of light chains

lambda and kappa

19

can an antibody have both lambda and kappa chain

no can either have 2 kappa or 2 lambda

20

how many domains are in the light chains of an immunoglobulin

2

21

how many isotypes do the heavy chains have

5

22

what are the 5 isotypes of heavy chains

Gamma, Mu, Alpha, Delta, Epsilon

23

what causes heavy chains to be different

1. number of domains
2. location of disulfide bond linking chains
3. presence of hinge region Hc
4. number and location of N linked carbohydrate groups
5. number of molecules present in secreted form

24

what does the hinge region provide in antibody

flexibility for binding to specific antigen

25

what enzyme cleaves on N terminal side of disulfide bond that link the immunoglobulin heavy chains

papain

26

what does Fab stand for

fragmented antigen binding

27

what does Fc stand for

fragment crystillizable

28

what enzyme cleaves on C terminal side of disulfide bond that link the immunoglobulin heavy chains

pepsin

29

how many framework regions are in both heavy and light chains

4

30

what does FR stand for

Framework region