B5.039 - Prework 2 Patterns of Glomerular Injury Flashcards Preview

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Flashcards in B5.039 - Prework 2 Patterns of Glomerular Injury Deck (39)
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1
Q

how do you describe all glomeruli

A

focal or diffuse

2
Q

what do focal and diffuse mean

A

focal - less that half

diffuse - half or more

3
Q

how do you describe a single glomerulus

A

segmental or global

4
Q

what do segmental or global mean

A

segmental - portions of glomerulus affected

global - entire glomerulus affected

5
Q

segmental or global

A

segmental

6
Q

segmental or global

A

global

7
Q

subtypes of hypercellularity

A

intrinsic - within glomerular tuft

extrinsic - in glomerulus but outside glomerular tuft

8
Q

types of intrinsic hypercellularity

A

mesangial, endocapillary, lobular

9
Q

types of extrisic hypercellularity

A

extracapillary, crescents

10
Q
A

normal glomerulus

11
Q

describe a normal capillary in the glomerulus

A

patent lumina, smooth GBM contours, small endothelial cells, inconspicuous podocytes

12
Q

describe a normal mesangium

A

1-3 cells per contiguous area; small amount of matrix

13
Q
A

endocapillary intrinsic hypercellularity

the cells are encroaching upon capillary lumina

hard to find open capillary lumina

14
Q
A

mesangial intrinsic hypercellularity

patent capillary lumina but misangeal matrix abnormal

15
Q
A

crescent extrinsic hypercellularity

16
Q
A

crescent extrinsic hypercellularity

silver stain highlights BM

17
Q

intrinsic HC often associated with what

A

immune complex deposition

18
Q

extrinsic HC often associated with what

A

GBM break/rupture

goodpasture, ANCA vasculitis…

19
Q
A

double contour BM

“tram tracking” extra BM laid down due to injury

20
Q

double contours typically due to what

A

endothelial/subendothelial injury

endothelial cells make new BM, so do podocytes if they need to

can be accompanied by mesangial cell migration (interpositioning) or immune cell infiltration

21
Q
A

mesangial matrix expansion

glue that holds everything together shows tons of matrix

22
Q
A

nodular mesangial expansion

seen in DM

23
Q

causes of MME

A

DM, HTN

immunoglobulin or immune complex deposition

24
Q
A

capillary pattern (granular) glomerular injury

25
Q
A

mesangial pattern glomerular injury

26
Q
A

GBM linear pattern think goodpastures

diffuse

27
Q

what are arrows pointing to

A

granular deposits

28
Q
A

fibrillar desposits

seen in amyloid

29
Q
A

tubular pattern

thumbprint deposit

seen in lupus

30
Q

when do you seen thrombosis in glomeruli

A

as part of thrombotic microangiopathy

also in DIC

31
Q

causes of TMA

A

SLE, HUS/TTP, PSS, HTN

32
Q
A

Fibrin thrombus

TMA

33
Q

tuft necrosis is associated with what

A

immune mediated injury

34
Q
A

tuft necrosis

nuclear debris, karyorexis

35
Q

insudate

A

when fluid passes thru capillary or epithelial cell and causes glassy appearance

36
Q
A

scar in glomerulus in bowmans space

37
Q
A

entire glomerulus scarred tf up

38
Q
A

segmental sclerosis

39
Q
A

scar with associated insudate (note glassy/hyaline apperance of cells at bottom)