Flashcards in Bacillus Deck (18):
Large square-end rods in chains
Facultative anaerobes or aerobes
Do Bacillus form endospores?
Which species of Bacillus is the only non-motile species?
Which Bacillus species is an obligate mammal parasite?
What animals are most often affected by Bacillus?
What is the source of infection?
Ingestion of soil contaminated with spores
What factors are needed for Bacillus virulence?
Capsule and tripartite anthrax toxin
What are the three parts of the tripartite anthrax toxin?
PA, EF, LF
Used for translocation into the cell
Protective antigen: Cell binding factor
Increases cAMP to cause edema
Edema factor: Calmodulin-dependent adenylate cyclase
Causes cell death and tissue injury and shock (necrosis and hemorrhage)
Lethal Factor: Zinc metalloprotease
What are 2 predisposing factors that increase exposure of animals to anthrax spores?
Previous anthrax history and buried carcasses and repeated cycles of flooding and evaporation
What is the most common mode of infection?
What PM indicators suggest anthrax infection?
Bleeding from orifices, splenomegaly
Is anthrax reportable?
What bio-safety level is anthrax?