Flashcards in Bacterial infections of skin and soft tissue II Deck (18):
Is strep pyogenes SENSITIVE to bacitracin? What about most beta hemolytic strep?
1. Yes 2. No
What are the GAS virulence factors?
Capsule, adhesins, toxins
What are the GAS adhesins?
F protein, M protein, LTA
What are the GAS toxins?
Streptolysin O and S, superantigens
What is the role of the GAS adhesin LTA?
Adheres to fibronectin on epithelial cell surface
What is the role of F protein and M protein GAS adhesins?
Invasion of epithelial cell
What is the most common cause of cellulitis?
Rheumatic fever is what type of hypersensitivity response to GAS?
What makes strep TSS different from staph TSS?
Many patients with streptococcal disease are bacteremic and many have necrotizing fasciitis
What is the gram stain for pseudomonas aeruginosa?
What is the oxidase test for pseudomonas?
What are the pseudomonas virulence factors?
Mucoid polysaccharide capsule, adhesins, secreted toxins and enzymes, antibiotic resistance
What comprises the pseudomonas polysaccharide capsule?
What are the pseudomonas aeruginosa toxins?
Exotoxin A and T3SS
What is the function of pseudomonas aeruginosa exotoxin A?
A/B toxin - inactivates EF-2 via ADP ribosylation - blocks protein synthesis
When does ecythma gangrenosum occur?
What is the most common cause of webspace intertrigo?