Bacterial infections of skin and soft tissue II Flashcards Preview

Year 1 Microbiology > Bacterial infections of skin and soft tissue II > Flashcards

Flashcards in Bacterial infections of skin and soft tissue II Deck (18):
1

Is strep pyogenes SENSITIVE to bacitracin? What about most beta hemolytic strep?

1. Yes 2. No

2

What are the GAS virulence factors?

Capsule, adhesins, toxins

3

What are the GAS adhesins?

F protein, M protein, LTA

4

What are the GAS toxins?

Streptolysin O and S, superantigens

5

What is the role of the GAS adhesin LTA?

Adheres to fibronectin on epithelial cell surface

6

What is the role of F protein and M protein GAS adhesins?

Invasion of epithelial cell

7

What is the most common cause of cellulitis?

Strep pyogenes

8

Rheumatic fever is what type of hypersensitivity response to GAS?

Type III

9

What makes strep TSS different from staph TSS?

Many patients with streptococcal disease are bacteremic and many have necrotizing fasciitis

10

What is the gram stain for pseudomonas aeruginosa?

Gram negative

11

What is the oxidase test for pseudomonas?

Positive

12

What are the pseudomonas virulence factors?

Mucoid polysaccharide capsule, adhesins, secreted toxins and enzymes, antibiotic resistance

13

What comprises the pseudomonas polysaccharide capsule?

Alginate

14

What are the pseudomonas aeruginosa toxins?

Exotoxin A and T3SS

15

What is the function of pseudomonas aeruginosa exotoxin A?

A/B toxin - inactivates EF-2 via ADP ribosylation - blocks protein synthesis

16

When does ecythma gangrenosum occur?

Pseudomonas septicemia

17

What is the most common cause of webspace intertrigo?

Pseudomonas aeruginosa

18

What is the treatment for pseudomonas aeruginosa?

Combination therapy with aminoglycosides and beta lactams