Bacterial Infections of the Lower Respiratory Tract II Flashcards Preview

Micro Exam II > Bacterial Infections of the Lower Respiratory Tract II > Flashcards

Flashcards in Bacterial Infections of the Lower Respiratory Tract II Deck (22):
1

What is the most common cause of walking pneumonia

mycoplasma pneumoniae

2

What is the most common cause of toxic pneumonia

legionella pneumophila

3

Treatment for atypical pneumonia

tetracycline and erythromycin

4

Characteristics of mycoplasma pneumoniae

no peptidoglycan
membrane contains sterols
fried egg colony morpholy
restricted to humans

5

How is mycoplasma pneumoniae spread

respiratory droplets

6

Virulence factor of mycoplasma pneumoniae

P1 adhesion

7

How does P1 adhesion work

binds to base of cilia, causes epithelial cell damage/death, and defect in mucociliary clearance

8

How do you confirm mycoplasma pneumoniae with lab tests

PCR, EIA

9

How do prevent mycoplasma pneumoniae disease

no vaccine
avoid overcrowded areas

10

Characteristics of chylamydophila pneumoniae

small, gram neg
obilgate intercellular pathogen

11

How can you confirm chylamdophilia pneumoniae with lab tests

microimmuofluorescence
PCR

12

What disease does chylamydophila pneumoniae cause

atypical (walking) pneumonia

13

Characteristics of legionella pneumophilia

gram negative
inside cells - coccobacilli
outside of cell -pleomorphic

14

Where is legionella pneumophila often found

freshwater lakes, streams, groud water, mud, riverbanks

15

What does legionella pneumophilia mainly exist as

parasites of amoeba

16

How does legionella pneumonphila get spread to humans

cooling towers/AC
respiratory therapy devices
the misting at the grocery stores

17

Virulence of legionella pneumophilia

target and attach to alveolar macrophage using pili, flagella, numerous proteins

18

Pathogenesis of legionella pneumophilia

prevents fusion with lysosome
makes stuff in the legionella containg vacuole
replicate to high numbers, the cell lyses, and the process starts over again

19

Symptoms of legionarries

chills, pleurisy, vomiting, diarrhea, confusion, delirium
elevated WBC count but no left band shift

20

What lab tests can you do to confirm it's legionella pneumophilia

DFA
nucleic acid amplifcation (however with both of these you get a lot of false negs)

21

How do you treat legionella pneumophilia

macrolide or fluoroquinolone

22

How do you prevent legionella pneumophilia

minimize exposure to/production of contaminated aerosols