Bacterial Toxins Flashcards Preview

(DIT) Rapid Fire + 4/5 Stars > Bacterial Toxins > Flashcards

Flashcards in Bacterial Toxins Deck (8)
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1
Q

Exotoxins

A

produced by and released by bacteria

Gram + w/ plasmids or bacteriophages coding for the exotoxin protein

antigenic- tetanus and diphtheria toxoid vaccines

2
Q

Neurotoxins

A

interfere w/ neural transmission

botulinum toxin, tetanus toxin

3
Q

Enterotoxins

A

affect intestines

Shigella, Vibrio cholerae

4
Q

Superantigens

A

exotoxins that bind MHCII receptor and T cell receptor simultaneously

  • -> polyclonal expansion of T cells
  • -> massive immune response w/ release of large amount of cytokines

S. aureus, S. pyogenes (group A strep)

5
Q

Endotoxin effect on macrophages

A

IL1, IL6 –> fever
TNF –> fever, cell death, cachexia
NO (vasodilator) –> hypotension, development of septic shock

6
Q

Endotoxin effect on complement

A

C3a (release histamine, increase vascular permeability) –> hypotension, development of septic shock

C5a –> N0 chemotaxis

7
Q

Endotoxin effect on tissue factor

A

Coagulation cascade –> DIC
-W/ gram - sepsis

microthrombi throughout body consumes coagulation factors and platelets –> bleeding issues

8
Q

Bacterial growth curve

A

Exponential/log phase: cell division
-vulnerable to abx, radiation

Stationary phase: spore formation, nutrient depletion, toxins accumulate

Death phase: prolonged nutrient depletion

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