BB LEC - ABO Blood System Part 3 Flashcards Preview

► Med Misc 05 > BB LEC - ABO Blood System Part 3 > Flashcards

Flashcards in BB LEC - ABO Blood System Part 3 Deck (19):
1

1% to 8% of __ individuals produce anti-A1 in their serum, and

A2

2

22% to 35% of __ individuals produce anti-A1

A2B

3

A subgroup
has more antigenic sites for the H antigen thus giving(+) rxn w/ Anti-H lectin)

A2 CELL

4

A subgroup

(H antigen sites occupied by both A and A1 antigens

A1 CELL

5

small agglutinates w/in predominantly unagglutinated red cells

Mixed field agglutination:

6

The Bombay phenotype was first reported by ___ in 1952 in Bombay, India

Bhende

7

inheritance pattern of Bombay phenotype

autosomal recessive

8

defect in Bombay phenotype
which gene

mutation in FUT1 (H gene) and FUT2 gene

9

antigens of Bombay phenotype

none

10

genotype of Bombay

hh

11

enzymes in serum present in Bombay

A or B depending on ABO genotype

12

Is the Bombay phenotype secretor or not

nonsecretor

13

genotype w/c is least reactive with Anti-H

A1B

14

are those rare phenotypes in which the RBCs are completely devoid of H antigens or have small amounts of H antigen present.

para-Bombay phenotypes

15

Do Bombay and para-Bombay phenotypes have H enzymes

no

16

The genetic basis for the para-Bombays is (2)

a mutated FUT1 (H gene) with or without an active FUT2 gene (Se gene) or a silenced FUT1 gene with an active FUT2 gene.

17

- a rare group 1 discrepancy.
- presence of two cell populations in single individual like in cases of fraternal twins

CHIMERISM

18

when bacterial enzymes (of Proteus vulgaris) modify N-acetylgalactosamine into D- galactose)

ACQUIRED B phenomenon

19

ACQUIRED B phenomenon - when bacterial enzymes (of what bacteria?) modify N-acetylgalactosamine into D- galactose)

Proteus vulgaris)

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