1. What is the most common spontaneous neoplasm of laboratory rabbits?
Adenocarcinoma of the uterus (ACU)
2. What is the most common spontaneous neoplasm of young and juvenile laboratory rabbits between the ages of 6-18 months?
ACU usually arises as multicentric foci. Death from metastasis does not occur until 12-24 months from clinical detection.
Tubular/solid adenocarcinomas (ACU) positively correlate with ER-α and PR expression
Papillary adenocarcinomas (ACU) negatively correlate with ER-α and PR expression
5. True or False: Breast changes other than neoplasia almost invariably accompany ACU.
6. Cervical cancer has neither been observed nor reported in the Oryctolagus rabbit likely because of this comparative difference:
The rabbit columnar epithelium of the uterus continues out over the cervix into the vagina and the transition to squamous epithelium occurs at the level of the urethral meatus.
7. This common tetrad of gross lesions is pathognomonic for lymphoma in Oryctolagus:
1. Enlarged, light tan kidneys with an irregular lumpy surface and thickened whitish cortex but normal medulla on cut surface 2. hepatomegaly with diffuse small pale foci 3. lymphadenopathy 4. splenomegaly.
8. Extensive renal infiltration by neoplastic cells in lymphoma can be reflected in this laboratory finding:
Terminally-elevated blood urea nitrogen due loss of over 65-75% of nephron functional capacity
9. The most common phenotype of lymphomas in Oryctolagus is:
Both T and B cell lymphomas are reported with equal frequency
10. True or False: the most common primary tumor of the spleen in Oryctolagus is hemangiosarcoma.
FALSE: no primary tumors of splenic tissue have been reported.
The rabbit VX2 tumor originated from a papilloma induced by Shope’s papilloma virus in a Dutch Belted male in the1940’s.
The VX2 tumor is known to secrete a hormone-like substance that depresses renal tubular reabsorption of phosphorus and causes hypophosphatemia, hypercalcemia, and dystrophic calcification of the tumor and soft tissues.
The VX2 tumor has never been reliably established in cell culture and is generally maintained by serial passage in rabbits.
12. When maintaining the tumor cell line, why is it important to harvest the tumor on day 14 postimplantation? a. The tumor has not yet progressed from the tubular/solid type to the papillary type. The papillary type loses ER-α and PR expression, which is essential for transplantability. b. Delaying harvest past 14 days results in morbidity and mortality due to pulmonary metastasis. c. Delaying harvest past 14 days results in poor tumor quality due to necrosis. d. A and B e. B and C
14. List the following naturally-occurring neoplasms of the laboratory rabbit in descending order of prevelance: a. Pituitary adenoma b. Adenocarcinoma of the uterus c. Embryonal nephroma d. Uterine lyomyosarcoma e. Mammary gland tumors f. Lymphoma/lymphoid leukemia g. Skin tumors
B, F, E, G, D, C, A
Incidence of this lesion
up to 80%
Most common neoplasia of what age rabbit?
Renal lymphoma - young animals
Most common mode of acquisition of this condition
inherited autosomal recessive bu/bu gene