Behcet's Syndrome

Question 1

What features are seen with Behcet’s Syndrome?

Answer 1

Recurrent oral and genital ulcers
Erythema nodosum
Anterior Uveitis- Acute painful red eye
Posterior Uveitis- painless 
Arthritis
Can also cause DVT and thrombophlebitis

Question 2

What skin sign is seen with Behcet’s syndrome?

Answer 2

Erythema nodosum-

Painful erythematous nodules mainly on the shins. Also folliculitis.

Question 3

What kind of disease is Behcet’s disease?

Answer 3

Behcet’s is a vasculitis disease- targets vessels of all sizes

Question 4

What differentiates the ulcers of Behcet’s disease from standard oral ulcers?

Answer 4

May take longer to heal
Larger
Multiple ulcers at various stages in healing

Also- co-existing genital ulcers with similar features

Question 5

What is the HLA association for Behcet’s disease?

Answer 5

HLA-B5

Question 6

What is the treatment for Behcet’s disease?

Answer 6

Immunosuppression- Steroids, AZA, cyclophosphamide
Biologics
IVIg

Colchicine for oral ulceration