Benzodiazepines Flashcards Preview

FRNSC 427 > Benzodiazepines > Flashcards

Flashcards in Benzodiazepines Deck (12):
1

Most frequently encountered benzodiazepines are

Alprazolam
Diazepam

2

Color Tests

Zimmerman-Reinhardt (Janovsky)

3

Analytical Methods

TLC
SPE
GC
LC/MS/MS

4

Benzodiazepines are what schedule type of drug?

Schedule IV

5

Substiuent Effects

Electron withdrawing group binds
*C-7 = enhanced activity
*C-2' = drug is more potent, increases amnesic effect
*N-1 = greater intrinsic effects
*C-3 = reduces duration of the drug and allows faster excretion
*if ring attaches to N-1 and C-2 = drug is more potent

6

pKa1 --> N-4 position

(+) --> neutral

7

pKa2 --> N-1. Position

Neutral --> (-)

8

Absorption

Highly lipophilic

Rapidly crosses blood-brain barrier and placental barrier

9

Administration

Oral
Intravenously
Intramuscularly

10

Benzodiazepines vary in

Dosage
Onset of action
Duration of action tendency to accumulate
Potency

11

Major binding protein

Albumin

12

Most forms of benzodiazepines are excreted

In urine form of the oxidized and glucuronide-conjugated metabolites

Amount of drug present in urine in elimination process is also dependent on type of benzodiazepine