BIOCHEM 1 - protein structure and organization Flashcards Preview

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Flashcards in BIOCHEM 1 - protein structure and organization Deck (34):
1

Defined by the amino acid sequence

primary structure

2

structure composed of Rigid planar peptide groups

primary structure

3

Rotation about the α-carbon
αC – Carbonyl Carbon

Ψ (psi):

4

Rotation about the α-carbon
αC – N

Ф (phi):

5

structure with Regular Folding

secondary structure

6

interaction in secondary structure

Interaction: H-bond between the amide proton and carbonyl oxygen

7

Spatial arrangement of the atoms in the polypeptide chain

secondary structure

8

The PRIMARY structure dictates the ____ structure.

Secondary

9

type of secondary structure having
Intramolecular H-bond

alpha helix

10

pitch of alpha helix

Pitch: 5.4 Å

11

aa residue per turn of alpha helix

3.6

12

Kinds of α – helix

right handed
left handed

13

where are the R-groups located in alpha helix

outside the helix

14

type of secondary structure
Intrachain or interchain H-bond

beta pleated sheet

15

Two types of beta sheet

Parallel pleated sheet
Antiparallel pleated sheet

16

Other secondary structures

Other helix structures
Random coils
Reverse turns or β bends

17

Combinations of α and β-strands

supersecondary structures

18

examples of supersecondary structures

Ex: βαβ unit, αα unit, β-meander and Greek key

19

– repetitive supersecondary structures

Motif

20

type of protein structure
Three-dimensonal arrangement

tertiary structure

21

Important aspect of tertiary structure

arrangement of the side chains of aa residues

22

Types of protein conformation

Globular proteins
Fibrous proteins

23

type of protein structure
Spatial arrangement of polypeptide subunits

quaternary structure

24

Interactions of quaternary structure:

same with tertiary structure

25

Loss of high level of structural organization of protein

denaturation

26

It is the sequence of amino acids linked by peptide bonds.
▪ The backbone of a peptide chain or protein.

primary structure

27

the location of prosthetic groups is shown in this structure

tertiary

28

structures which repeat over and over in a secondary structure

supersecondary structure

29

disulfide bonds are most important in this type of structure

tertiary structure

30

a supersecondary region, often shared by protein, having a specific function

domain

31

vitamin necessary for hydroxyproline synthesis

C

32

AA important in holding 3 strands of collagen together

hydroxyproline

33

fibrous proteins can be composed of either helical or Beta sheet structures, true or false

TRUE

34

Independently folded regions of proteins

domains

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