Biogenic Amines Flashcards Preview

MCB 2 Block 3 > Biogenic Amines > Flashcards

Flashcards in Biogenic Amines Deck (18):
1

Creatine

From Arginine and is a reservoir of energy to maintain ATP support for large muscle groups. Accepts Phosphate from ATP via creatine kinase making creatine phosphate
(G=10kcal/mol)

2

Creatine Synth

Glycine to GuanidineAcetate via Arginine in kidney
GuanidineAcetate to Creatine via SAM in liver
Moves to large muscle groups

3

Creatine Degrade

Spont cyclization of C-P to Creatinine (no enzyme)
Urinary Creatinine is a measure of kidney malfunction and index of N balance

4

NO

From Arginine
Dilates vascular smooth muscle
Block platelet aggregation
Neurotrans
Bacteriocidal Inflamm response

5

NO synth

Rxn of Arg to Citrulline
Via nitric oxide synthase
Rqrs: FMN, FAD, heme, NADPH, BH4
Electron from is from NADPH to FAD to FMN to Heme to Oxygen

6

GABA

From glutamate; is an inhib neurotransmitter
Rqrs PLP and releases CO2

7

Histamine

Active in mast cells. Decarb of histidine (rqrs PLP and - CO2)
Inactivation via Deamination; methylation (SAM) and deamination by MAO (in brain)

8

Histamine pathway draw

On paper

9

Serotonin

From tryptophan and mods physio functions
Try to 5-hydroxytryptophan (Tryptophan hydroxylase; rqrs BH4 and O2) to Serotonin (DOPA decarboxylase; rqrs PLP and loses CO2)

10

Melatonin

From Serotonin: produced by pineal, lymphocytes, BM; activated by darkness and is a strong antioxidant
Serotonin to N-acetyl Serotonin (via Acetyl CoA) to Melatonin (via SAM)

11

Catecholamines

From Tyrosine = NE and Epi from Dopamine

12

Catecholamine Synth

2 tyrosines to DOPA (Via Tyrosine hydroxylase; rqrs BH4) to Dopamine (DOPA decarboxylase; rqrs PLP loses CO2) to NE (via Dopamine beta-hydroxylase; rqrs O2, Vit C, Ca) to Epi (via phenylenthanol amine transferase; rqrs SAM)

13

Catecholamine Degradation

Via MAO (cleans excess NT's, releases NH4) and CAMT (catechol-o-methyl transferase; rqrs SAM) and and oxidation
Final product is VMA

14

Parkinsons

early degrade of dopamine CNS cells leading to bradykinesia

15

Thyroid hormones

From tyrosine; ctrld via TSH, I transport via Na/I pump

16

TH syth

Tgb to Tgb w/DIT (requires Hydrogen peroxide and I) to Tgb with T4 (coupling) to T3 and T4 (lysosomal)

17

Melanin

From Tyrosine
Pheomelanin - pink/red = light skin and red hair and is carcinogenic with UV
Eumelanin - brown/black and activated by UVB, primary function is to dissipate UVB
Neuromelanin - Brain and S. Nigra with possible anti-ROS activity

18

Melanin Synth

2 tyrosine to DOPA (via tyrosine hydroxylase and is Ca dependent) to Melanin. All in melanocytes

Rqrs Tyrosine and Cysteine
1st rxn = Tyrosine (UVB induced) to Dopa to dopaquinone
2nd rxn = dopaquinone and cysteine to pheomelanin to eumelanin