Inflammation
Tissue response to limit spread of injury
Types of inflammation
Acute - vasoconstriction
Chronic - WBC’s
Anti-inflammatory drugs
NSAIDS - pain=aspirin
Glucocorticoids - fever= paracetamol
Oedema
Excess fluid in interstitial tissue
Fluid pressures in/out cell
INTO - plasma pressure (IPP)
OUT - capillary pressure (OCP)
Types of tissue repair
Regeneration - cell regenerates
Replacement - cell replaced with connective tissue
Types of cells (LSP - do, can, don’t)
Labour - do replicate
Stable - can replicate
Permanent - donor
Phases of healing
Inflammation (prepares)
Proliferation (builds)
Remodelling (shrinks)
Pathogenesis of atherosclerosis
High LDLs
Fat streaks
Plaque accumulation
Atheroma (degeneration)
Aneurysm
Blood filled pocket attached to vessel
Types of hypertension (3)
Primary - no cause
Secondary - underlying disease
Malignant - progressing
Define thrombus
Blood clot
Haemorrhage
Internal bleeding
Thrombus pathogenesis
Injury > clotting > prevention
What is Virchow Triad
Factors that promote a thrombus
Virchow triad factors
Change in…
Wall
Flow
Composition
Pharmacological management of conditions
Anti-platelet — aspirin (inhibits function)
Anti-coagulant — heparin (inhibits fibrin)
Fibrinolytic —RTPA (breaks down)
Myocardial oxygen consumption MVO2
More work = more oxygen needed
Myocardial ischemia
Insufficient oxygen for demands
Types of myocardial ischemia
Part blockage = angina
Full blockage = myocardial infarction (heart attack)