Biological Rhythms & Sleep - Martin Flashcards Preview

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Flashcards in Biological Rhythms & Sleep - Martin Deck (13):
1

Seasonal affective disorder (SAD)

- Possibly caused by out of sun circadian rhythms
- Sxs: hopelessness, increased appetite, increased sleep, social withdrawal
- Tx: light therapy

2

What is the master circadian pacemaker?

Suprachiasmatic nucleus

3

Zeitgeber

- Environmental stimulus entraining (mainly light)
- Rhythms become free running when no zeitgeber present

4

What activators and target genes are involved in the auto regulatory transcriptional feedback loop of the circadian clock?

Activators: CLOCK & BMAL1
Genes: Per1, Per2, Cry1, Cry2

5

What things are people who work night shifts more at risk for?

Obesity, heart disease, breast cancer, colon cancer

6

Dec2

- A negative component of circadian clock
- Mutation in this gene produces reduced sleep time

7

Alpha waves

Initial sleep stage; 8-13 cycles/second

8

Beta waves

2nd sleep stage; > 13 cycles/second

9

Theta waves

3rd sleep stage; 4-7 cycles/second

10

Delta waves

4th stage of sleep; < 4 cycles/second

11

Tueromamillary nucleus (TMN)

Responsible for producing awake state

12

What do histamine containing cells in the TMN promote?

Wakefullness

13

Ventrolateral preoptic nucleus

Supresses the TMN and leads to slow wave sleep