Biologics Flashcards
(41 cards)
1
Q
Traditional drugs
A
- synthetic organic compounds
- defined structure, physical and chemical characteristics
- small MW
- linear dose response
- biotransformed
- NOT species specific
2
Q
Biologics
A
- protein, carb, nucleic acid structures
- extracted from living organism
- large MW
- heat and shear sensitive
- non linear dose response
- species dependent
3
Q
u
A
human
4
Q
o
A
mouse
5
Q
xi
A
chimeric
6
Q
zu
A
humanized
7
Q
Biologics elimination
A
RES
antigen specific target mediated disposition
8
Q
Common side effects of biologics
A
- infusion site reactions
- allergic reactions
- flu like symptoms
- N/D
- decreased blood cell counts
9
Q
Etanercept
A
- anti-TNF
- TNF receptor
- shortest DOA
- RA, psoriasis, psoriatic arthritis
10
Q
Side effects etanercept
A
Ha, allergic reaction, rash, URI
11
Q
BBW anti TNF drugs
A
for serious infections, malignancies
12
Q
Infliximab
A
- anti-TNF
- partially humanized
- Crohn’s disease, ulcerative colitis
13
Q
Infliximab side effects
A
CV effects
14
Q
adalimumab
A
- anti-TNF
- fully humanized
15
Q
Adalimumab side effects
A
- develop antibodies against drug
- cause demyelination
16
Q
CI adalimumab
A
patients with demyelinating diseases (MS)
17
Q
bevacizumab
A
- angiogenesis inhibitor
- stops formation of new blood vessels, inhibit VEGF
- treat cancers, eye diseases
18
Q
BBW bevacizumab
A
hemorrhage, delayed wound healing and GI perforations
19
Q
Abciximab
A
- GPIIb/IIIa antagonist
- prevent platelet aggregation
- percutaneous coronary intervention
20
Q
Side effects abciximab
A
- bleeding
- thrombocytopenia
- allergy
21
Q
Omalizumab
A
- IgE inhibitor
- moderate to severe asthma
22
Q
BBW omalizumab
A
for anaphylaxis presenting as bronchospasm
23
Q
side effects omalizumab
A
- injection site reactions
- CV events
24
Q
Pembrolizumab
A
- Block PD1
- humanized
- cancers
25
Side effects pembrolizumab
- rash (SJS)
- fatigue
- T1D
26
Nivolumab
- block PD1
- fully human
- metastatic cancer
27
Side effects of nivolumab
- Rash (SJS)
- adrenal insufficiency
- T1D
- GI toxicity: diarrhea, colitis
28
What can nivolumab be used with?
ipilimumab (synergistic)
| - metastatic melanoma
29
Atezolizumab
- block PD-L1
- humanized
- metastatic lung cancer
- metastatic urothelial carcinoma
30
Side effects of anti PD-L1 drugs
- adrenal insufficiency
- CV toxicity
- T1D
- infection risks
31
avelumab
- block PD-L1
- fully human
- Merkel cell carcinoma
- advanced metastatic urothelial carcinoma
32
durvalumab
- block PD-L1
- fully human
- metastatic urothelial carcinoma
33
Ipilimumab
- CTLA-4 inhibitor
- fully human
- metastatic and non-metastatic melanoma
34
BBW ipilimumab
- immune mediated reactions (months to weeks after treatment stops)
35
CTLA-4 inhibitor drugs
ipilimumab
36
PD-L1 inhibitor drugs
- atezolizumab
- avelumab
- durvalumab
37
PD-1 inhibitor drugs
- pembrolizumab
| - nivolumab
38
IgE inhibitor drugs
- omalizumab
39
Anti platelet drugs
- abciximab
40
Malignancies drugs
- bevacizumab
41
Anti-TNF drugs
- etanercept
- infliximab
- adalimumab
