Biologics Flashcards
1
Q
Traditional drugs
A
- synthetic organic compounds
- defined structure, physical and chemical characteristics
- small MW
- linear dose response
- biotransformed
- NOT species specific
2
Q
Biologics
A
- protein, carb, nucleic acid structures
- extracted from living organism
- large MW
- heat and shear sensitive
- non linear dose response
- species dependent
3
Q
u
A
human
4
Q
o
A
mouse
5
Q
xi
A
chimeric
6
Q
zu
A
humanized
7
Q
Biologics elimination
A
RES
antigen specific target mediated disposition
8
Q
Common side effects of biologics
A
- infusion site reactions
- allergic reactions
- flu like symptoms
- N/D
- decreased blood cell counts
9
Q
Etanercept
A
- anti-TNF
- TNF receptor
- shortest DOA
- RA, psoriasis, psoriatic arthritis
10
Q
Side effects etanercept
A
Ha, allergic reaction, rash, URI
11
Q
BBW anti TNF drugs
A
for serious infections, malignancies
12
Q
Infliximab
A
- anti-TNF
- partially humanized
- Crohn’s disease, ulcerative colitis
13
Q
Infliximab side effects
A
CV effects
14
Q
adalimumab
A
- anti-TNF
- fully humanized
15
Q
Adalimumab side effects
A
- develop antibodies against drug
- cause demyelination
16
Q
CI adalimumab
A
patients with demyelinating diseases (MS)
