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Flashcards in Bipolar disorder Deck (14):
1

What is Disruptive Mood dysregulation?

Recurrent temper outbursts in response to common stressors
- begins at age 10
-at least 3 per week
-occurs in at least 2 settings

2

What are some examples of emotional regulation?

- reactive attachement disorder
-infants of depresses mothers
- fetal alcohol spectrum disorder
- PTSD
- Personality disorders

3

What are the genetic states behind bipolar 1 disorder?

50-80% twin-twin
- up to 85% heritability

4

What are some neurophysiologic characteristics of bipolar disorder?

Limbic hyperactivity
- deactivation in the inferior frontal cortex or ventrolateral prefrontal cortex
- not in euthymic and depressed states

5

what are the 2 hypothesis' fro monoamine hypothesis?

-Monoamine hypothesis
-Neurotransmitter receptor hypothesis

6

What is the suicide rate for bipolar disorder and MD?

>10% and

7

What is axis I and axis II?

Mood, attn, and substance abuse for I
- 2= personality disorders

8

What are the only 2 drugs that have shown to demonstrate reduction in suicidal thoughts?

Lithium carbonate and clozapine?

9

What are some of the side effects of depkote?

Hepatotoxicity and thrombocytopenia

10

What should one monitor for a pt on Tegretol?

Agranulocytosis
hepatotoxicity

11

What are some atypical antipsychotics? AKA neuroleptics

risperidone (Risperdal)
olanzapine (Zyprexa)
quetiapine (Seroquel)
ziprasidone (Geodon)
aripiprazole (Abilify)
asenapine (Saphris)
iloperidone (Fanapt)
Haloperidol (Haldol)
Fluphenazine (Prolixin)
Thioridazine (Mellaril)
Chlorpromazine (Thorazine)

12

What is neuroleptic malignant syndrome?

Potentially fatal condition with loss of body temp regulation, renal and respiratory failure, ANS impairment and LOC

13

What is the treatment for acute mania?

Lithium, Valproic acid and carbamazepine
- 2nd line neuroleptics
- ECT

14

What is the treatment for acute/chronic depression?

-Stage 1 is lamotrigine (Lamictal) +/- mood stabilizer or neuroleptic
-Stage 2 is quetiapine (Seroquel) or olanzapine (Zyprexa) + fluoxetine (Prozac) combination
-Later stages involve other antidepressants + an antimanic agent