BLG111 Quiz Chapter 22 Flashcards

1
Q

List the correct order of structures through which air moves from when it enters the body at the mouth and nose to the alveoli in the lungs.

A

Air enters into the upper respiratory tract through the nose and nasal cavity and through the pharynx into the lower respiratory tract by way of the larynx and trachea. Air eventually enters the bronchi and its branches and is absorbed the lungs and alveoli.

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2
Q

Write the formulae for Boyle’s Law and Henry’s Law and describe in words the important principle described by each.

A

Boyle’s law: the relationship between pressure and volume of a gas (i.e., gases always fill the container they are in - volume and gas are inversely proportional) pressure=1/volume

Henry’s Law: the amount of gas that dissolves in a solution depends on its partial pressure and its solubility

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3
Q

What four processes does respiration involve?

A
  1. Pulmonary ventilation (breathing): movement of air into and out of lungs
  2. External respiration: exchange of O2 and C02 between lungs and blood
  3. Transport: of O2 and CO2 in blood via the circulatory system
  4. Internal respiration: exchange of O2 and CO2 between systemic blood vessels and tissues via circulatory system
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4
Q

What is the Pharynx?

A

Passageway connecting nasal cavity to larynx and oral cavity to esophagus. Three subdivisions: nasopharynx, oropharynx, and laryngopharynx. A passageway for air and food and houses the tonsils.

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5
Q

What is the Larynx?

A

Connects the pharynx to the trachea. Houses the vocal folds that act in voice production and acts as an airway passage; can prevent food from entering the lower respiratory tract.

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6
Q

What are the three layers that comprise the trachea?

A

See slide 7 for the photomicrograph.
1. Mucosa: ciliated pseudostratified epithelium with goblet cells
2. Submucosa: connective tissue with seromucous glands supported by 16-20 C-shaped cartilage rings that prevent collapse of trachea
3. Adventitia: outermost layer made of connective tissue (i.e., hyaline cartilage)

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7
Q

Why does a person develop a “smokers cough”?

A

Smoking inhibits and ultimately destroys cilia. Without ciliary activity, coughing is only way to prevent mucus from accumulating in the lungs.

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8
Q

Air passages undergo how many orders of branching within the bronchial tree?

A
  1. Much of it is a conduction region, bringing air deeper into the lungs; however, some areas are for gas exchange.
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9
Q

Why is it critical that bronchioles have the ability to change their luminal diamete?

A

Because they are highly reactive they can create either high resistance or high airflow into the lungs. High resistance may be seen during anaphylaxis.

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10
Q

What histological changes occur in the conducting zone from bronchi to bronchioles?

A

The supporting structures change (i.e., elastic fibers replace cartilage); epithelium type changes (i.e., pseudostratified columnar gives way to cuboidal and cilia and goblet cells become more sparse); amount of smooth muscle increases

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11
Q

What are the respiratory zone structures?

A

The respiratory zone begins where terminal bronchioles feed into respiratory bronchioles, which lead into alveolar ducts and finally into alveolar sacs - the sites of actual gas exchange

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12
Q

What is the function of alveolar pores?

A

They connect adjacent alveoli and equalize air pressure throughout the lungs

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13
Q

What if the function of type II alveolar cells?

A

They secrete surfactant that breaks down surface tension if any fluid gets into the airway and allow the alveoli to inflate properly

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14
Q

Driving pressures create the flow of gas, for air to be encouraged into our lungs, we need a good atmospheric pressure - this is generally considered sea level which is…?

A

760mm Hg

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15
Q

What is a pneumothorax?

A

Rupturing either of the parietal or visceral pleura

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16
Q

Describe the sequence of inspiration

A
  1. Inspiratory muscles contract and diaphragm descends; rib cage rises
  2. Thoracic cavity volume increases
  3. Lungs are stretched; intrapulmonary volume increases
  4. Intrapulmonary pressure drops to (-1 mm Hg)
  5. Air (gases) flows into lungs down its pressure gradient until intrapulmonary pressure is 0 (equal to atmospheric pressure)
17
Q

Describe the sequence of expiration

A
  1. Inspiratory muscles relax; diaphragm rises, rib cage descends due to recoil of costal cartilages
  2. Thoracic volume decreases
  3. Elastic lungs recoil passively; intrapulmonary volume decreases
  4. Intrapulmonary pressure rises (1 mm Hg)
  5. Air (gases) flows out of lungs down its pressure gradient until intrapulmonary pressure is 0
18
Q

What three physical factors influence the ease of air passage and the amount of energy required for ventilation?

A
  1. Airway resistance
  2. Alveolar surface tension (i.e., created by fluid in the lungs)
  3. Lung compliance (i.e., how stretchable)
19
Q

What is IRDS?

A

Infant Respiratory Distress Syndrome and is caused by the insufficient quantity of surfactant in premature infants. Increased surface tension results in collapse of alveoli after each breath.

20
Q

What is Tidal Volume?

A

Amount of air inhaled or exhaled with each breath under resting conditions

21
Q

What is Residual Volume?

A

Amount of air remaining in the lungs after a forced expiration

22
Q

What is Total Lung Capacity?

A

Maximum amount of air contained in lungs after a maximum inspiratory effort
TLC = TV + IRV + ERV + RV

23
Q

What is Vital Capacity?

A

Maximum amount of air that can be expired after a maximum inspiratory effort
VC = TV + IRV + ERV

24
Q

What is the difference between external and internal respiration?

A

External respiration is the diffusion of gases between blood and lungs; Internal respiration is the diffusion of gases between blood and tissues

25
Q

What is Dalton’s Law of Partial Pressures?

A

Total pressure exerted by mixture of gases is equal to sum of pressures exerted by each gas. The sum of all partial pressures from each contributing gas.

26
Q

What is the partial pressure of oxygen at sea level?

A

20.9% and 159 mm Hg

27
Q

How is molecular oxygen carried in the blood?

A

1.5% is dissolved in plasma
98.5% is loosely bound to each Fe of hemoglobin (Hb) in RBCs

28
Q

What is a partially saturated heme?

A

When only one to three hemes carry O2. Fully saturated is where all four heme groups carry O2

29
Q

What is venous reserve?

A

Oxygen remaining in venous blood that can still be used

30
Q

How is CO2 transported in the blood?

A
  1. Dissolved in plasma 7 to 10% as PCO2
  2. As bicarbonate ions in plasma (about 70%)
  3. Chemically bound to hemoglobin (just over 20%)
31
Q

What is Hypoxia?

A

Inadequate O2 delivery to tissues; can result in cyanosis and is classified by cause

32
Q

What are the medullary respiratory centers?

A

Clustered neurons in two areas of medulla:
1. Ventral respiratory group: consists of a network of neurons in brain stem that excite inspiratory muscles via phrenic (diaphragm) and intercostal nerves that set the normal respiratory rate and rhythm
2. Dorsal respiratory group: network of neurons that integrates input from peripheral stretch and chemoreceptors, then sends information to VRG neurons

33
Q

What are the Pontine respiratory centers?

A

Neurons in this center influence and modify the activity of VRG. They act to smooth out the transition between inspiration and expiration and vice versa.

34
Q

Respiratory centers are affected by…?

A

Chemical factors, influence of higher brain centers, pulmonary irritant reflexes, inflation reflex