Block 1 - Epithelial Tissue Flashcards Preview

Histology > Block 1 - Epithelial Tissue > Flashcards

Flashcards in Block 1 - Epithelial Tissue Deck (26):
1

What is the core of a microvilli made of?

Actin filaments bound by actin binding proteins (fimbrin or fascin)

2

How are microvilli anchored to the membrane?

Lateral anchoring proteins eg. myosin 1

3

What are stereocilia related to and where are they found?

Microvilli
Epididymis (absorption)
Inner ear cochlea (sense receptors)

4

What is primary ciliary dyskinseia?

Genetic defect in ciliar proteins cause uncordinated or absent beating
Dextrocardia
Impair development of sinuses
No mucous removal in lungs
Infertility

5

What are three types of junctions found on the lateral domain?

Occluding junctions, anchoring junctions, and communicating junctions

6

Zonula Adherens

Lateral domain, cell to cell
Actin filaments
Cadherin

7

What important role does cadherin play? What happens when it is lost?

Controls cell behavior and its loss is associated with acquisition of invasive behavior by tumor cells

8

Macula adherens

"Desmosome"
Spot-like
Intermediate fillaments
Intracellular plaque - desmoplakin
Caherin transmembrane proteins

9

What are intercellular channels made of? What type of junction are they?

Communicating junction
Pair of Connexons, each with 6 protein subunits
Occur in patches

10

Where is collagen IV found in basement membrane?

Basal Lamina

11

What type of collagen is in reticular lamina?

Thin collagen fibers, type III

12

Focal Adhesions

Actin, basement membrane
Talin - peripheral protein
Integrin (C++ independent family") -tm

13

Hemidesmosome

Intermediate fillaments
Integrin
Desmoplakin

14

What is glandular epithelium made out of?

Invagination of epithelial tissue (cuboidal cells normally(

15

What is the difference between endocrine and exocrine glands?

Endocrine excrete materials into intercellular space and CT, diffusing into blood
Exocrine secrete into ducts of spaces lined with originating epithelium

16

What are three types of excretion of exocrine glands?

Merocrine (mucous, serous, or mixed), apocrine, and holocrine

17

What is product delivered to merocrine glands? How does the product leave the cell?

Membrane bound vesicles, which fuse with plasma membrane and release content via exocytosis

18

What are differences between serous and mucous merocrine glands?

Serous have better developed RER and their cavity (serous acini) is rounded shape due to pyrimidal cells

Mucous glands stain light (barely any). Cells are columnar, therefore their cavity is columnar in shape

19

How are mixed glands both mucous and serous?

Mucous cells create tube, serous cells cap forming demilunes. Submandibular gland

20

How do apocrine glands secrete their material? Where can they be found?

Pinching of apical cytoplasm, forming secretory vesicles. Found in mammary glands.

21

How do holocrine glands secrete material?

Apoptosis involving the whole cell, releasing material into lumen of gland

22

What is the most common type of unicellular gland?

Goblet cells

23

Where are unicellular glands most commonly found?

Non-secretory epithelium

24

What is a duct?

The portion of a multicellular gland that connects the secretory portion to the surface of epithelium

25

What are two types of secretory portions?

Alveolar (flask shaped)
Tubular (tube shaped)

26

How are myoepithelial cells involved with glands?

Help expel material out of gland between basal lamina and secretory portion