Flashcards in Block 1 - Epithelial Tissue Deck (26):
What is the core of a microvilli made of?
Actin filaments bound by actin binding proteins (fimbrin or fascin)
How are microvilli anchored to the membrane?
Lateral anchoring proteins eg. myosin 1
What are stereocilia related to and where are they found?
Inner ear cochlea (sense receptors)
What is primary ciliary dyskinseia?
Genetic defect in ciliar proteins cause uncordinated or absent beating
Impair development of sinuses
No mucous removal in lungs
What are three types of junctions found on the lateral domain?
Occluding junctions, anchoring junctions, and communicating junctions
Lateral domain, cell to cell
What important role does cadherin play? What happens when it is lost?
Controls cell behavior and its loss is associated with acquisition of invasive behavior by tumor cells
Intracellular plaque - desmoplakin
Caherin transmembrane proteins
What are intercellular channels made of? What type of junction are they?
Pair of Connexons, each with 6 protein subunits
Occur in patches
Where is collagen IV found in basement membrane?
What type of collagen is in reticular lamina?
Thin collagen fibers, type III
Actin, basement membrane
Talin - peripheral protein
Integrin (C++ independent family") -tm
What is glandular epithelium made out of?
Invagination of epithelial tissue (cuboidal cells normally(
What is the difference between endocrine and exocrine glands?
Endocrine excrete materials into intercellular space and CT, diffusing into blood
Exocrine secrete into ducts of spaces lined with originating epithelium
What are three types of excretion of exocrine glands?
Merocrine (mucous, serous, or mixed), apocrine, and holocrine
What is product delivered to merocrine glands? How does the product leave the cell?
Membrane bound vesicles, which fuse with plasma membrane and release content via exocytosis
What are differences between serous and mucous merocrine glands?
Serous have better developed RER and their cavity (serous acini) is rounded shape due to pyrimidal cells
Mucous glands stain light (barely any). Cells are columnar, therefore their cavity is columnar in shape
How are mixed glands both mucous and serous?
Mucous cells create tube, serous cells cap forming demilunes. Submandibular gland
How do apocrine glands secrete their material? Where can they be found?
Pinching of apical cytoplasm, forming secretory vesicles. Found in mammary glands.
How do holocrine glands secrete material?
Apoptosis involving the whole cell, releasing material into lumen of gland
What is the most common type of unicellular gland?
Where are unicellular glands most commonly found?
What is a duct?
The portion of a multicellular gland that connects the secretory portion to the surface of epithelium
What are two types of secretory portions?
Alveolar (flask shaped)
Tubular (tube shaped)