Block 13 Flashcards Preview

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Flashcards in Block 13 Deck (21):
1

Ciprofloxacin
Class
Gram +ve/-ve
Use
MOA
Considerations

Fluoroquinolone antibiotic
Gram +ve and -ve
Inhibits topoisomerase II and IV -> inhibiting bact. DNA replication
Can cause c.diff inf.

2

Cisplatin
Class
Use
MOA
Considerations

Anticancer
Testicular/lung/cervix/bladder/head + neck and ovary
Alkylating agent - cross links DNA -> apoptosis
Nephrotoxicity

3

Ethambutol
Class
Use
MOA

Anti-tuberculotic
TB
Arabinosyl transferase inhibitor - req. for micobacterial cell wall synth.

4

Isoniazid
Class
Use
MOA

Anti-tuberculotic
Prodrug: inhibit synth of mycolic acid req. for mycobacterial cell wll synth.

5

Paclitaxel
Class
Use
MOA

Anticancer (taxane)
ovarian/breast/lung, Kaposi’s sarcoma/cervical/pancreatic
Binds tubulin, prevents chromosome transport during mitosis

6

Pyrazinamide
Class
Use
MOA

Antituberculotic
TB
Pro-drug: activated in mycobacterium
Reduces FA synthesis
Disrupts memb. potential
Inhibits translation (binds ribosomes)

7

Rifampacin
Class
Use
MOA

RNA synthesis inhibitor
TB
Inhibits RNA polymerase

8

Budesonide
Class
Use
MOA
Considerations

Corticosteroid
Asthma, allergic rhinitis, Crohn's, UC
Glucocorticoid receptor agonist
Candadiasis, cushings

9

Ipratropium
Class
Use
MOA

mACh antagonist
Asthma, COPD, Allergic rhinitis
Selectively inhibits mACh receptors, decrease in smooth muscle tone

10

Montelukast
Class
Use
MOA

Leukotriene receptor antagonist
Asthma, allergic rhinitis
CysLT1 receptor antagonist, inhibits IL-5 release (attracts eosinophils)

11

Salbutamol
Class
Use
MOA

SABA (short acting beta 2 agonist)
Asthma, COPD
Stimulates B2 -> smooth muscle relaxation + bronchodilation

12

Salmeterol
Class
Use
MOA

LABA (Long acting B2 agonist)
COPD, asthma
Stimulates B2 -> smooth muscle relaxation, bronchodilator

13

Adenosine
Class
Use
MOA

Purine receptor agonist
SVT
Activates A1 and A2 adenosine receptors. Inhibits slow calcium channels -> relaxation of vascular smooth muscle

14

Amiodarone
Class
Use
MOA

K+ channel inhibitor (class III)
SVT and VT
Prolongs myocardial AP
grey skin discolouration, photosensitivity

15

Atenolol
Class
Use
MOA

Beta Blocker
HTN, angina, tachycardia, AMI
Blocks B1 receptors, inhibiting adrenaline/noradrenaline form binding
Negatively chronotropic

16

Atropine
Class
Use
MOA

mACh antagonist
Bradycardia
Competes with ACh for mACh receptor: inhibits parasympathetic activity on the heart -> increased SAn firing

17

Diltiazem
Class
Use
MOA
Considerations

Calcium channel blocker
HTN, stable angina
Inhibits calcium influx - inhibits smooth muscle contr.
-vasodilation -> increased O2 supply, decr. peripheral resistance, decr. systemic BP,decr. afterload

N+V, dizziness, agitation, confusion

18

Glyceryl trinitrate (GTN)
Class
Use
MOA

Nitrate
Angina
Conversion to NO -> incr. cGMP -> decr. intracell. Ca2+ -> smooth muscle relaxation

19

Lidocaine
Class
Use
MOA

Na+ channel inhibitor (Class 1b)
Resusc., VT, anaesthesia/analgesia
Slows depololarisation of myocytes, Increases stimulation threshold of ventricles. Shortens AP duration. No effect on SA node

20

Verapamil
Class
Use
MOA
Considerations

Ca2+ channel inhibitor (Class IV)
SVT, paroxysmal tacchyarrhythmias, Angina, HTN
Inhibits L type Ca2+ channels -> negative ionotropic and chronotropic effects -> decr. HR + BP
Profound cardiac depressant

21

Digoxin
Class
Use
MOA

Cardiac glycoside
AF, atrial flutter
Inhibits Na+/K+-ATPase exchanger -> incr. intracell Na+
Na+/Ca2+ exchanger -> incr. in intracell Ca2+ -> positive ionotropic effect.