Block 2_7 - Adrenal Steroids

Question 1

Name 5 Glucocorticoid / Mineralcorticoids to know

Answer 1

Aldosterone

Cortisol

Dexamethasone

Prednisolone

Fludrocortisone

Question 2

Metyrapone

1. mechanism of action
2. result of action
3. other info
4. Use

Answer 2

Synthesis inhibitors

1. Blocks 11-ß Hydroxylation so synthesis is stopped at 11-desoxycortisol
2. 11-desoxycortisol does not inhibit ACTH release so plasma ACTH levels increase
3. ACTH stimulates synthesis and excretion of 17-hydroxycorticoids as 11-desoxycortisol
4. diagnose adrenal insufficiency

Question 3

Mifepristone

1. mechanism
2. use #1
3. use #2

Answer 3

1. competitive antagonist at progesterone and glucocorticoid receptor
2. progesterone receptor antagonist - termination of pregnancy
3. glucocorticoid receptor antagonist - treat Cushing Disease

Question 4

Spironolactone

Eplerenone

1. what is it
2. use #1
3. Use #2
4. Use #3

Answer 4

1. competitive antagonists at mineralcorticoid receptor
2. diuretcs
3. treat hypertension
4. cardiac hypertrophy and heart failure

Question 5

Drospirenone

1. Agonist
2. Antagonist
3. Antagonist

Answer 5

1. Progesterone Receptor Agonist (major Use)

• used with estrogen to suppress ovulation
• used with estron as hormone replacement therapy in post-menopausal women

2. Mineralcorticoid receptor antagonist

• diuretic
• Antagonizes the salt retaining effect of estrogen

3. Androgen receptor antagonist