Flashcards in Block 4 Lecture 3 -- Psychosis: Schizophrenia Deck (48)
What are the types of schizophrenia?
2) disorganized (hebephrenic)
What are sxs of catatonic schizophrenia?
withdrawn; little to no movement;
-- possibly vegetative
What are sxs of disorganized (hebephrenic) schizophrenia?
verbally incoherent; flat effect; inappropriate emotions or behavior
What are sxs of paranoid schizophrenia?
delusion; hallucinations; false beliefs of grandeur
What are sxs of residual schizophrenia?
-- negative symptoms remain
-- most other sxs have disappeared
What are sxs of undifferentiated schizophrenia?
multiple symptom types
What is a hallucination?
hearing/seeing/feeling things that aren't real
What is a delusion?
holding unusual beliefs not shared by others
What are causes of psychosis?
3) HIV or other infection
abnormal condition of the mind; loss of contact with reality
chronic brain disorder affecting thinking, feeling, and actions
-- not a split/multiple personality
What are positive symptoms of schizophrenia?
3) disorganized speech/thinking
4) grossly disorganized behavior
5) catatonic behaviors
6) psychomotor agitation
What are negative symptoms of schizophrenia?
1) affective flattening
5) attentional deficits
6) social withdrawal
lack of motivation for initiating tasks
difficulty or inability to speak
lack of interest/enjoyment in life
What are cognitive sxs of schizophrenia?
1) slow/disorganized thinking
2) difficulty understanding
3) poor concentration, memory
4) difficulty expressing and integrating thoughts/feelings/behavior
-- impaired attention, memory, and executive function
What are the mood sxs of cognitive schizophrenia?
What are the symptom categories of schizophrenia?
What are the current hypotheses for schizophrenia pathophys?
1) DA hypothesis
2) serotonin hypothesis
3) Glu hypothesis
4) GABA hypothesis
What structural abnormalities are present in schizophrenia?
1) enlargement of lateral ventricles
2) slight reduction in cerebral cx thickness
3) reduced total brain volume
What are the 4 main brain DA pathways?
-- VTA to NA, HP, Amygdala
-- VTA to FCx
-- SN to striatum
-- HT to AP
What is the role of the ML system in schizophrenia?
positive sxs; worsened by DA
What is the role of the MC system in schizophrenia?
negative sxs; mitigated by DA
What is the role of the NS system in schizophrenia?
posture and involuntary movement; worsened by DA
What is the role of the TI system in schizophrenia?
involved with ADRs
-- DA decreases PRL release
Describe the DA hypothesis of schizophrenia.
1) ML system overactive
2) MC system underactive
-- disturbed, hyperactive dopaminergic system
-- hyperactivity of D2r
What is DA's function in the CNS (effects)?
3) motor function (fine tuning)
What are the strengths of the DA hypothesis in schizophrenia?
-- amphetamines increase DA to produce psychotic symptoms
-- antipsychotic drugs (block DA) reduce positive sxs