Block 4 Lecture 3 -- Psychosis: Schizophrenia Flashcards Preview

PHS 931 > Block 4 Lecture 3 -- Psychosis: Schizophrenia > Flashcards

Flashcards in Block 4 Lecture 3 -- Psychosis: Schizophrenia Deck (48)
Loading flashcards...
1

What are the types of schizophrenia?

1) catatonic
2) disorganized (hebephrenic)
3) paranoid
4) residual
5) undifferentiated

2

What are sxs of catatonic schizophrenia?

withdrawn; little to no movement;
-- possibly vegetative

3

What are sxs of disorganized (hebephrenic) schizophrenia?

verbally incoherent; flat effect; inappropriate emotions or behavior

4

What are sxs of paranoid schizophrenia?

delusion; hallucinations; false beliefs of grandeur

5

What are sxs of residual schizophrenia?

long-term
-- negative symptoms remain
-- most other sxs have disappeared

6

What are sxs of undifferentiated schizophrenia?

multiple symptom types

7

What is a hallucination?

hearing/seeing/feeling things that aren't real

8

What is a delusion?

holding unusual beliefs not shared by others

9

What are causes of psychosis?

1) schizophrenia
2) bipolar/unipolar
3) HIV or other infection
4) genetics
5) drug-induced

10

Define psychosis.

abnormal condition of the mind; loss of contact with reality

11

Define schizophrenia.

chronic brain disorder affecting thinking, feeling, and actions
-- not a split/multiple personality

12

What are positive symptoms of schizophrenia?

1) delusions
2) hallucinations
3) disorganized speech/thinking
4) grossly disorganized behavior
5) catatonic behaviors
6) psychomotor agitation

13

What are negative symptoms of schizophrenia?

1) affective flattening
2) avolition
3) alogia
4) anhedonia
5) attentional deficits
6) social withdrawal

14

Define avoliton.

lack of motivation for initiating tasks

15

Define alogia.

difficulty or inability to speak

16

Define anhedonia.

lack of interest/enjoyment in life

17

What are cognitive sxs of schizophrenia?

1) slow/disorganized thinking
2) difficulty understanding
3) poor concentration, memory
4) difficulty expressing and integrating thoughts/feelings/behavior

-- impaired attention, memory, and executive function

18

What are the mood sxs of cognitive schizophrenia?

1) depression
2) dysphoria
3) hopelessness
4) demoralization
5) anxiety
6) guilt

19

What are the symptom categories of schizophrenia?

1) positive
2) negative
3) cognitive
4) mood

20

What are the current hypotheses for schizophrenia pathophys?

1) DA hypothesis
2) serotonin hypothesis
3) Glu hypothesis
4) GABA hypothesis

21

What structural abnormalities are present in schizophrenia?

1) enlargement of lateral ventricles
2) slight reduction in cerebral cx thickness
3) reduced total brain volume

22

What are the 4 main brain DA pathways?

1) mesolimbic
-- VTA to NA, HP, Amygdala
2) mesocortical
-- VTA to FCx
3) nigrostriatal
-- SN to striatum
4) tuberoinfundibular
-- HT to AP

23

What is the role of the ML system in schizophrenia?

positive sxs; worsened by DA

24

What is the role of the MC system in schizophrenia?

negative sxs; mitigated by DA

25

What is the role of the NS system in schizophrenia?

posture and involuntary movement; worsened by DA

26

What is the role of the TI system in schizophrenia?

involved with ADRs
-- DA decreases PRL release

27

Describe the DA hypothesis of schizophrenia.

1) ML system overactive
2) MC system underactive
-- disturbed, hyperactive dopaminergic system
-- hyperactivity of D2r

28

What is DA's function in the CNS (effects)?

1) reward
2) pleasure
3) motor function (fine tuning)
4) compulsion
5) perserverance

29

What are the strengths of the DA hypothesis in schizophrenia?

-- amphetamines increase DA to produce psychotic symptoms
-- antipsychotic drugs (block DA) reduce positive sxs

30

What are weaknesses of the DA hypothesis?

1) amphetamines only mimic positive sxs; FGAs only reduce positive sxs
2) D2r blockade is rapid, but clinical effects take weeks
3) studies show no change in DAr density
4) hallucinogens and anesthetics also cause dose-dependent psychotic sxs