Flashcards in Blood And Bone Marrow Response To Infection Deck (7)
What are some characteristic features of a lymphocyte under a gram stain?
- blue cytoplasm
- clumped chromatin
- typically without granules
What are some common features of a virus infection in a blood film? Name some examples of viral infections.
Thrombocytopenia - low platelet count
Reactive T cells - increased size, basophilic cytoplasm
Examples of viral infection: Epstein-Barr Virus EBV, cytomegalovirus CMV, varicella, Viral Hepatitis, Dengue fever, Parvovirus
Outline the process of EBV driven lymphoma formation
EBV proliferates in B cells and then turns off its antigens to evade the immune response. In immunocompromised hosts, the virus selects abnormal B cells which proliferate to form a lymphoma
What are some of the features of Bordetella pertussis infection on a gram stain? What's the common name for the infection?
Lymphocytosis - increased lymphocytes due to a lymphocyte promoting factor secreted by the bacteria that inhibits lymphocyte migration to the tissues
Leucocytosis - lots of WBC's, indicates infection
Common name is Whooping Cough
What is haemophagocytosis? How does it alter blood cells (in terms of their count)? What infections is it associated with?
Macrophages phagocytose haemopoietic cells in the bone marrow
Causes pancytopenia - cytopenia all multiple cell types (leucopenia, anaemia, thrombocytopenia)
Associated with any infections - viral (EBV, CMV, varicella), bacterial, fungal, protozoal
Name 3 characteristics of parvovirus in a gram stain.
Anaemia - caused by reduced erythropoiesis
Giant erythroblasts with viral inclusions