Flashcards in BM1022 5 Deck (9):
Hypersensitivity can be defined as an abnormal state of immune reaction that can have deleterious effects on the host.
There are normal and, in most cases, essential immune responses that are exaggerated to the point that damage occurs.
Type 1 - immediate hypersensitivity reactions
Type 2 - cytotoxic hypersensitivity
Type 3 immune complex mediated disease
Type 4- delayed type hypersensitivity
Immune deficiencies can be classified as primary, where there is a deficiency in the gene resulting in the lack of a function that is important, and secondary
Where there is an external influence affecting the immune response
Primary immune deficiencies
These occur when there is a deficient gene responsible for the production of one or more proteins Essential for a normal immune response
The deficiency may affect only a small part of the immune system or result in a combined immunodeficiency with disastrous consequences, if it affects a fundamental part of the development of both T and B cells
Secondary immune deficiencies
These can result from a variety of factors including malnutrition, renal failure, diabetes, burns, the effect of drugs including immunosuppressants as well as infectious diseases such as HIV