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Flashcards in BM1022 5 Deck (9):
1

Hypersensitivity

Hypersensitivity can be defined as an abnormal state of immune reaction that can have deleterious effects on the host.

There are normal and, in most cases, essential immune responses that are exaggerated to the point that damage occurs.

4 TYPES

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Type 1 - immediate hypersensitivity reactions

PAPER

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Type 2 - cytotoxic hypersensitivity

Paper

4

Type 3 immune complex mediated disease

Paper

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Type 4- delayed type hypersensitivity

Paper

6

Immune deficiencies

Immune deficiencies can be classified as primary, where there is a deficiency in the gene resulting in the lack of a function that is important, and secondary
Where there is an external influence affecting the immune response

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Primary immune deficiencies

These occur when there is a deficient gene responsible for the production of one or more proteins Essential for a normal immune response

The deficiency may affect only a small part of the immune system or result in a combined immunodeficiency with disastrous consequences, if it affects a fundamental part of the development of both T and B cells

8

Secondary immune deficiencies

These can result from a variety of factors including malnutrition, renal failure, diabetes, burns, the effect of drugs including immunosuppressants as well as infectious diseases such as HIV

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Autoimmunity

Autoimmunity occurs when tolerance fails. Either antibodies or T cells recognise self antigens and a series of reactions occur that cause host cell and tissue damage.
All 4 types of hypersensitivity occur


Conditions include: lupus, type I diabetes and rheumatoid arthritis