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Flashcards in Bone Deck (7)
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1

The Normal Skeleton composition

2

Normal Skeleton

Inorganic Matrix

• Calcium hydroxyapatite

[Ca10(PO4)6(OH)2]

– Mineral homeostasis

• 99% of calcium stores

• 85% of phosphate stores

• 65% of sodium and magnesium stores

3

Bone Cells

– Osteoprogenitor cells -> Osteoblasts ->

Osteocytes

– Hematopoietic progenitor cells -> Osteoclastic

precursors -> Osteoclasts

4

Bone Matrix

– Type 1 Collagen (29%)

– Non-collagenous proteins (3%) – Serum

5

Organic Components of Bone

Bone Cells

Bone Matrix

6

Organic Matrix

Osteoblasts

• Synthesize proteins

• Initiate mineralization • Bind hormones

• Make bone

• Regulate osteoclasts

Osteoid (matrix)

12-15 days osteoid to bone formation 

Bone (mineralized matrix)

7