Bone Pathology II: Bone Neoplasms Flashcards Preview

Pathology > Bone Pathology II: Bone Neoplasms > Flashcards

Flashcards in Bone Pathology II: Bone Neoplasms Deck (25):
1

Are primary bone neoplasms rare?

YES

2

Osteoma

Benign tumor like mass of abnormally dense bone

3

Where are osteomas commonly found?

Skull

4

What age do osteomas typically appear?

4th to 5th decade

5

- Osteomas
- Epidermal cysts
- Fibromatoses
- Colonic adenomatous polyposis

Gardner's Syndrome

6

Osteoid Osteoma

Benign highly vascular and well-circumscribed osteoblastic proliferation that is almost always singular

7

Where are osteoid osteomas typically found?

Long bones

8

What is the characteristic appearance of osteoid osteoma on x-ray?

Targetoid Appearance

9

Osteosarcoma

High grade sarcoma most often seen younger patients and presents as a painful tender mass

10

What is the most common location of osteosarcoma?

Knee

11

Codman Triangle

Triangular shadow between the cortex and raised ends of periosteum as the tumor has broken through the cortex and lifted the periosteum

12

Osteochondroma

Outgrowth of medullary and cortical bone covered with a cartilaginous cap that is more of a malformation than a neoplasm

13

Osteochromatosis

Multiple hereditary osteochondromas

14

Chondrosarcoma

Malignant cartilage forming tumor

15

What gender is more affected by chrondrosarcoma?

Males

16

Ewing's Sarcoma

Primary osseous neoplasm of small and round mesenchymal cells which are rich in cytoplasmic glycogen

17

What is the chromosome tranlocation seen in Ewing's sarcoma?

Ch11:Ch22 translocation

18

What is the result of the t(11;22) translocation in Ewing's sarcoma?

EWS/FLI-1 gene fusion which over expresses MIC2

19

Fibrous Dysplasia

Benign intramedullary proliferaton of fibrous and bone tissue

20

What is the radiographic appearance of fibrous dysplasia?

Ground Glass

21

- Polyostotic fibrous dysplasia
- Precocious pubert
- Unilateral macular pigmented skin lesions
- Fibromyxomatous soft tissue tumor
- Recurrent fractures

McCune-Albright's Syndrome

22

What mutation is McCune-Albright's Syndrome associated with?

GNAS-1 mutation

23

Giant Cell Tumor of Bone

Locally aggressive bone neoplasm with large number of osteoclast-like giant cells with mononuclear cells in background

24

What are common metastases to the bone?

- Prostate
- Breast
- Kidney
- Lung

25

What are common metastases in children to the bone?

- Neuroblastoma
- Wilm's tumor
- Rhabdomyosarcoma

Decks in Pathology Class (203):