Bordetella, Pseudomonas Flashcards Preview

POD Exam II > Bordetella, Pseudomonas > Flashcards

Flashcards in Bordetella, Pseudomonas Deck (12):
1

Bordetella pertussis (6):

- Capable of invading respiratory tract.
- Recurrent, violent cough that can last up to 6 weeks.
- Encapsulated coccobacillus.
- Non-fermentative.
- Gram negative rods.
- Nutritionally fastidious.

2

Bordetella pertussis virulence factors (7):

Adhesins:
- Filamentous hemagglutinin (FHA).
- Pili and pertactin.
Toxins:
- Pertussis toxin.
- Invasive adenylate cyclase.
- Dermonecrotic toxin (lethal toxin).
- Tracheal cytotoxin.
- LPS - Lipid A and X

3

Pertussis diagnosis methods (2):

- Direct fluorescent antibody (DFA).
- PCR

4

Pseudomonas aeruginosa (7):

- Gram negative rod.
- Non-fermenter.
- Motile with flagella.
- Aerobic.
- Simple growth requirement.
- Ubiquitous.
- Green and blue pigments.

5

Pseudomonas aeruginosa virulence factors (6):

- Exotoxin A.
- Exoenzyme S.
- Elastase.
- Phospholipase C/Heat-stable phospholipase.
- Alkaline phosphotase.
- Alginate.

6

Exotoxin A:

ADP-ribosylation of EFII.

7

Exoenzyme S:

ADP-rybosylates several proteins. Type III secretion system.

8

Phospholipase:

Hydrolysis of phospholipids leading to tissue damage.

9

Alkaline phosphotase:

Proteolysis leading to tissue damage.

10

Alginate:

Promotes adherence to respiratory epithelium, interferes with effective phagocytosis and may be immunostimulatory.

11

Pseudomonas folliculitis:

Resulting from immersion in contaminated water such as hot tubs, whirlpools, swimming pools.

12

Three pathogens can colonize the CF lung:

- S. aureus.
- H. influenzae.
- P. aeruginosa.