Borellia & Rickettsiae Flashcards Preview

Bacteriology Lectures > Borellia & Rickettsiae > Flashcards

Flashcards in Borellia & Rickettsiae Deck (23):
1

Other organism that can fit into this category

Yersinia pestis

2

Borrelia organism size, shape, and visualization

 

.4um

spirochete (long)

Light microscope visible

 

3

Borrelia gran staining

 

Gram negative

*but NO LPS

4

Borrelia contains _________ in outer membrane

 

inflammatory proteins

(OspA + OspC)

5

B recurrentis and B hermsii cause _____.

 

Three stages of symptom progession?

 

Relapsing fever

  • General bacteremia (within one week)
  • Sudden onset fever, subsides in 3-5 days
  • Recurrence of symptoms 5-10 days

6

Symptom recurrence of B. recurrentis + hermsii caused by _________

Antigenic variation

 

may go through 5-10 cycles

7

What is the most common Borellia?

What does it cause?

burgdorfi

Lyme disease

8

Symptoms of lyme disease (early, and chronic)

 

Early = Flu-like, erythema chronicum migrans

*Early disseminated symptoms = CN7 palsy, meningitis

Chronic infection = arthritis, joint pain (may affect heart and nerves)

9

What is behind the pathology of borrelia symptoms?

 

Autoimmune antibodies

10

Is borrelia Human > Vector > Human transmission possible?

Only with recurrentis (relapsing fever borrelia)

11

B. recurrentis spread via ______

human louse

(innoculated when louse is scratched into skin)

12

B. hermsii is spread via...

soft-bodied ticks from rodent reservoir

 

(transovarian cycle in the tick)

13

Many ticks in western US are infected with B. hermsii, but...

 

outbreaks are rare

14

B. burgdorferi spread via...

Deer tick nymph (lxodes scapularis)

 

*from deer, mouse, or bird reservoir

15

Up to ___% of ticks are infected with B. burgdorferi

 

50%

16

Main virulence factor for B. recurrentis + hermsii

antigenic variation

17

Antigenic variation of borrelia is based on ________

 

VMP protein antigen

  • *Most population has one form, but a few mutants have another one
  • *host antibodies select against the mutants

18

Borrelia (recurrentis and hermsii) latency is when...

 

relapse is when...

Latency = most of the population has been killed

Relapse = mutant variety grows to repopulate

19

B.burgdorferi antigenic variation

 

doesn't occur

20

Why do you get multiple rounds of symptoms with burgdorferi if it doesn't undergo antigenic variation?

Probably a second infection with a different strain of burgdorferi

21

Preventive control of B. burgdorferi

hygenic delousing

long pants

check body for ticks

22

Antibiotics for Borellia

 

Doxycycline or synthetic penicillins

*Can use 3rd gen ceph for recalcitrant (uncooperative) infections

23

Borrelia vax?

No effective vax

OspA vax developed in 90's but withdrawn