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Flashcards in Breast Deck (130)
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1

Who would you find inflammtory carcinoma in

Young black women

2

Tx for intraduct pupilloma

Excision of whole duct system

3

What is associated with mucinous (colloid) carcinoma

solid/non-invasive papillary carcinoma

4

What are the known breast ca genes a risk factor for heriditary breast ca

BRCA1 (chr 17q21) BRCA2 (chr13q12) Triple negative phenotype (ER-/PR-/HER2 neu-)

5

Age cystocarcoma phyllodes

5-6th decade female

5

What are risk factors for sporadic breast ca

Gender most important Early menarche Late menopause Estrogen therapy Radiation exposure Carcinoma of contralateral breast Living in US Fat Enziro toxins

6

Risk factors for heriditary breast ca

germline mutations Known breast ca gene

6

Clinic- Unilateral pruritic erythematous eruption with scale crust... mistaken for eczema

Pagets

6

What are the time restrictions set on ER/PR

Time from tumor removal to initiation of fixation should be kept to one hour or less Fixation to buffered formalin must extend for at least 6 hours and no longer than 72 hours

7

Age for galactocele

Young women

8

Minor prognostic factors of breast ca

histo subtype, grade, ER/PR receptors HER2/neu, LVI, proliferative rate

9

Clinic Older women Gross- soft pale/blue/grey node Well differentiated

Mucinous (colloid) carcinoma type of lobular carcinoma in situ

10

What is noted to be protective to sporadic breast CA

Early preganancy age

10

Breast ca lab tests

FNAC, needly bx, lumpectomy Nipple aspiration, ductal lavage, random periareolar FNA Core needle biopsy

10

Basal like

13-25% ductal carcinoma Trip negative BRCA1+ younger females, Higher grade, aggressive -> mets to brain cure possible in ctx group

10

Prognosis for mucinous carcinoma

Good prognosis

10

Clinic- Fleshy, soft node Well diff Lab- Synctyial sheets of large oval cells little stroma Lymphoplasmacytic immune response

Medullary carcinoma type of lobular carcinoma in situ (2%)

11

Micro- Branching papillae in lumen FIbrovascular core Double layer of epithelial cells No atypia/mitosis

Intraduct papilloma

12

Benign phyllodes tumour

13

Galactocele

Cystic dilatation of obstructed duct (during lactation) • Painful fluctuant lump

13

Prognosis of Paget

Related to underlying carcinoma

14

What does intraduc papilloma arise from

Lumen of large duct

14

MArkers for Paget

ER negative Overexpression of HER2NEU

15

Late stage traumatic fat necrosis presents with

Lymphocytes, fibrosis, cysts and CALCIFICATIONS

16

CLinic- Hard irregular lump on breast Boarders not well defined

Sclerosing adenosis RR1.5-2

17

Ductal carcinoma types

Comedo (high grade) Non comedo (solid, cribriform, papillary, micropapillary) Pagets

18

Amastia

Congenital absence of breast-

19

Proliferative dz w/o atypia

RR- 1.5-2.0 Sclerosing adenosis Florid benign hyperplasia Radial scar Papilloma Fibroadenoma w/ complex features

19

Clinical- Skin retraction Upper outer quadrant Axillary lymphadenopathy Skin thick around hairfollicles

Breast ca

20

Multiple papillomas located deeper within ductal system

Small duct papillomas