Who would you find inflammtory carcinoma in
Young black women
Tx for intraduct pupilloma
Excision of whole duct system
What is associated with mucinous (colloid) carcinoma
solid/non-invasive papillary carcinoma
What are the known breast ca genes a risk factor for heriditary breast ca
BRCA1 (chr 17q21) BRCA2 (chr13q12) Triple negative phenotype (ER-/PR-/HER2 neu-)
Age cystocarcoma phyllodes
5-6th decade female
What are risk factors for sporadic breast ca
Gender most important Early menarche Late menopause Estrogen therapy Radiation exposure Carcinoma of contralateral breast Living in US Fat Enziro toxins
Risk factors for heriditary breast ca
germline mutations Known breast ca gene
Clinic- Unilateral pruritic erythematous eruption with scale crust... mistaken for eczema
Pagets
What are the time restrictions set on ER/PR
Time from tumor removal to initiation of fixation should be kept to one hour or less Fixation to buffered formalin must extend for at least 6 hours and no longer than 72 hours
Age for galactocele
Young women
Minor prognostic factors of breast ca
histo subtype, grade, ER/PR receptors HER2/neu, LVI, proliferative rate
Clinic Older women Gross- soft pale/blue/grey node Well differentiated
Mucinous (colloid) carcinoma type of lobular carcinoma in situ
What is noted to be protective to sporadic breast CA
Early preganancy age
Breast ca lab tests
FNAC, needly bx, lumpectomy Nipple aspiration, ductal lavage, random periareolar FNA Core needle biopsy
Basal like
13-25% ductal carcinoma Trip negative BRCA1+ younger females, Higher grade, aggressive -> mets to brain cure possible in ctx group
Prognosis for mucinous carcinoma
Good prognosis
Clinic- Fleshy, soft node Well diff Lab- Synctyial sheets of large oval cells little stroma Lymphoplasmacytic immune response
Medullary carcinoma type of lobular carcinoma in situ (2%)
Micro- Branching papillae in lumen FIbrovascular core Double layer of epithelial cells No atypia/mitosis
Intraduct papilloma
Benign phyllodes tumour
Galactocele
Cystic dilatation of obstructed duct (during lactation) • Painful fluctuant lump
Prognosis of Paget
Related to underlying carcinoma
What does intraduc papilloma arise from
Lumen of large duct
MArkers for Paget
ER negative Overexpression of HER2NEU
Late stage traumatic fat necrosis presents with
Lymphocytes, fibrosis, cysts and CALCIFICATIONS
CLinic- Hard irregular lump on breast Boarders not well defined
Sclerosing adenosis RR1.5-2
Ductal carcinoma types
Comedo (high grade) Non comedo (solid, cribriform, papillary, micropapillary) Pagets
Amastia
Congenital absence of breast-
Proliferative dz w/o atypia
RR- 1.5-2.0 Sclerosing adenosis Florid benign hyperplasia Radial scar Papilloma Fibroadenoma w/ complex features
Clinical- Skin retraction Upper outer quadrant Axillary lymphadenopathy Skin thick around hairfollicles
Breast ca
Multiple papillomas located deeper within ductal system
Small duct papillomas
