Breast Flashcards Preview

Path > Breast > Flashcards

Flashcards in Breast Deck (130)
Loading flashcards...
83

Gynecomastia

Male analog of FCC Increased estrogen levels Linked to cirrhosis, klinefleter (XXY) drugs Find button like nodule beneath areola Micro: intraductal hyperplasia

85

What are the non breast ca genes increase your risk for heriditary breast ca

Li Fraumeni syndrome (p53) Li Fraumeni varient (CHEK2) Peutz Jeghers syndrome Cowden syndrome Ataxia telengectasia

87

Intraduct carcinoma in large duct with spread to skin, areola, nipple

Paget dz

88

ER/PR response tx

ER+/PR+: Respond to tamoxifen ER-/PR+: Upto 50% response rate ER+/PR-: 40% response rate ER-/PR-:

90

Module can grow from small to taking up entire breast

cystocarcoma

91

Histo- Thickened secretion, dilation, rupture of duct Inflammation, granular debris Foamy histocytes, mononuclear cells Plasma cells and granulomas

Duct ectasia

93

Peaud- orange

Lymphedema Skin thick around hairfollicles

95

Milky discharge

pituitary adenoma, hypothyroidism, drugs (birth control)

96

Non preliferative epithelial lesions

RR- 1 Simple FCC

97

Grade I

well differentiated (score 3-5)

98

ER/PR testing is done how

immunohistochemistry Considered positive test if at least 1% of tumor in the sample tests positive Predicts benefit with endocrine tx

99

Clinical Lumpiness “lumpy bumpy”, pain, tenderness - continuous or cyclical, mammographic densities/calcifications Bilateral Grows with hormones

Fibrocystic changes (FCC)

100

Polymastia

Accessory true mammary gland (can be found in arm pit)

101

Increase risk for CA from fibroadenoma when

Cyst larger than .3 cm Sclerosing adenosis, epithelial calcifications and papillary apocrine change

102

Uncommonly metastasizing lobular carcinomas

colloid, medullary, papillary

103

Are cystocarcoma phyllodes benign or mallignant

benign

104

Luminal B

15-20% ductal carcinomas ER+, HER2Neu (Trip positive tumor) LN mets Respond to ctx

105

mistaken for carcinoma

Congenital inversion of nipple

106

Lab- Large hyperchromic nucleus w/ halo Aggressive underlying intraductal carcinoma

Pagets

107

BRCA2 characteristics

Chrom 13q12 10-20% ovarian ca in carrier Increased risk of male breast ca Prostatic/pancreatic ca

108

Carcinomas in males

.11% lifetime risk Klinefelters BRCA2 mutation rapid infiltration ER+ tumor more common

109

Grade III

Poorly differentiated score >7

111

When does fibroadenoma regress

During menopause

112

What is the most common non skin malignancy in females

Breast carcinoma

113

Borderline phyllodes tumour

Moderate atypia 5-10 HPF (high power field), pushing bordres

114

Implants can lead to

Abscess Foreign body granuloma Fistulae

115

Postive mamograph can indicate

60-80% carcinomas Intraduct carcinoma FCC proliferative, sclerosing adenosis, radial scar

117

Gross- Lobulated clefts leaf like Micro- Leaf like architecture, nuclear pleomorphism, cellularity, mitotic rate, stromal overgroth INFILTRATIVE BORDER

Phyllodes tumour

118

Normal breast like

6-10% ductal carcinomas ER+, HER2/Neu-ve Usually well differentiated

119

Proliferative dz w/ atypia

RR- 4-5 Atypical ductal hyperplasia Atypical lobule hyperplasia