Breast Cancer Flashcards Preview

Hugh's MD2 Gen Med > Breast Cancer > Flashcards

Flashcards in Breast Cancer Deck (17):
1

What can be used if a patient is Her2 positive?

Herceptin

2

When is total mastectomy indicated?

When the patient is a carrier of a high risk gene - eg BRCA1 or 2

Or when wide local excision and radiotherapy is contraindicated

2

What is the mechanism of action of aromatase inhibitors?

Block the conversion of testosterone to oestrogens to reduce the tissue concentration of oestrogen

2

What lifestyle factors can be modified to reduce the risk of breast cancer reoccurence?

Avoid weight gain

Exercise

 

3

Where does breast cancer metastasize to?

Bone

Lung/liver

Brain 

4

What are the two endocrine therapy for breast cancer?

Oestrogen receptor antagonist - tamoxifen

Aromatase inhibitors - eg Anastrozole

5

What types of cancers on FHx that increase the risk of breast cancer?

Breast cancer

Ovarian cancer

Prostate

Familial gastric cancer

6

What investigations are helpful in breast Ca?

Ultrasound

Mammography

Biopsy

 

7

What types of biopsies are there for breast Ca?

Fine needle aspirate

Core biopsy

Incisional biopsy

Excisional biopsy

8

What is the most likely diagnosis of a new lump in a young woman?

Fibroadenoma

Cyst

Fibrocyst tissue

Cancer

9

When is radiotherapy contraindicated?

When it has been performed previously

When the patient has scleroderma

11

Why does obesity increase the risk of breast cancer?

It increases the person's exposure to oestrogen

12

What is the recommended breast cancer screening?

1 mammography every two years for women 50-75 years

14

What regimen provides better reduction of risk of recurrence of breat cancer; total mastectomy or wide local excision and radiotherapy?

They are equvalent

15

What is tamoxifen?

An oestrogen receptor antagonist

16

Which ethnic group have a higher rate of BRA1 and 2?

Eastern European Jew - Ashkenazi

17

What must you consider when giving a female patient chemotherapy?

Fertility - Chemotherapy induces menopause