Bugs with exotoxins Flashcards Preview

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Flashcards in Bugs with exotoxins Deck (15):
1

Corynebacterium diphtheriae

Diphtheria toxin

Inactivate EF2

Pharyngitis with pseudomembranes in throat and severe lymphadenopathy

2

Pseudomonas aeruginosa

Exotoxin A

Inactivate EF2

Host cell death

3

Shigella

Shiga toxin

Inactivate 60S ribosome by removing adenosine from rRNA

GI mucosal damage: dysentry; ST also enhances cytokine release, causing HUS

4

EHEC

Shiga-like toxin

Inactivate 60S ribosome by removing adenosine from rRNA

Cytokine release, causing HUS
does not invade host cells

5

ETEC (labile)

Heat-labile toxin

Overactivates cAMP leading to increased Cl secretion in gut and H2O efflux

watery diarrhea

6

ETEC (stable)

Heat-stable toxin

Overactivate cGMP, decreases resorption of NaCl and H2O in gut

watery diarrhea

7

Bacillus anthracis

Edema factor

Mimics cAMP

Edematous borders of black eschar

8

Vibrio cholerae

Cholera toxin

Overactivates cAMP by permanently activating Gs, increases Cl section in gut and H2O efflux

lots of rice-water diarrhea

9

Bordetella pertussis

Pertussis toxin

Overactivates cAMP by disabling Gi, imparing phagocytosis

Whooping cough

10

Clostidium tetani

Tetanospasmin

Cleave SNARE

Muscle rigidity and lock jaw (prevents release of GABA and glycine)

11

Clostridium botulinum

Botulinum toxin

Cleave SNARE

Flaccid paralysis, floppy baby, prevents ACh release

12

Clostridium perfringens

Alpha toxin

Phospholipase that degrades tissue and cell membranes

Degradation of phospholipase C --> gas gangrene and hemolysis

13

Strep pyogenes

Streptolysin O

Degrades cell membrane

Lyses RBCs

14

S aureus

Toxic shock syndrome toxin 1

superantigen

fever, rash, shock (toxic shock syndrome)

15

Strep pyogenes (TSS)

Exotoxin A

superantigen

fever, rash, shock (toxic shock syndrome)

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