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Flashcards in Bullous disorders Deck (13)
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1
Q

Blisters in bullous impetigo and scalded skin syndrome are caused by:

A

Exfoliative toxin released by staphylococcus

2
Q

In bullous impetigo, the blisters are made at what location?

A

at the local site of infection

3
Q

in staph scalded skin syndrome (SSSS), the blisters occur where?

A

throughout the body (due to circulating toxin)

4
Q

what differentiates staph scalded skin syndrome from SJS?

A

the blisters involve the skin only, not mucous membranes

5
Q

what protein does the exfoliative toxin of staph bind to and cleave?

A

desmoglein 1

6
Q

what differentiates SSSS and toxic epidermal necrolysis (TEN)?

A

SSSS involves the epidermis, TEN involves the subepidermis

7
Q

What is the definition of nikolsky sign?

A

the dislodgement of epidermis by shearing (rubbing something along the surface recreates the blister)

8
Q

What is another name for staph scalded skin?

A

Ritter disease

9
Q

where do blisters occur in SSSS?

A

areas of mechanical stress - axilla, flexion areas, buttocks

10
Q

do scars occur in SSSS?

A

no. because the cleavage of skin is intraepidermal

11
Q

how do you diagnose SSSS?

A

culture blood, urine, nasopharynx, umbilicus or any suspected focus of infection. can also be confirmed by skin biopsy (can differentiate SSSS from TEN)

12
Q

what is the etiology of toxic epidermonecrolysis? (TEN)

A

usually a drug reaction

13
Q

what is the treatment of SSSS?

A

usually treated with penicillinase-resistant penicillin (oxacillin) or vancomycin (in areas of high MRSA prevalence) + supportive emollients