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Flashcards in Buzz Words 2 Deck (100):
1

Congenital Disease: deletion in chromosome 22

Di George

2

Congenital Disease: Translocation of Chromosome 21
(Give 4)

- ALL
- AML
- CML
- Down

3

Congenital Disease: Trisomy of Chromosome 13

Patau

4

Congenital Disease: Trisomy of Chromosome 18

Edwards

5

Congenital Disease: Trisomy of X Chromosome

Triple X Syndrome
Kleinfelter
Think learning disability

6

Microbio Tests: CAMP Test

GBS
GBS vs GAS

7

Microbio Tests: ELEK Test

Corynebacterium diphtheria
Identify toxin producing strains

8

Microbio Tests: Germ Tube Test

Candida

9

Microbio Tests: Weil-Felix Test

Ricketssia
Proteu vulgaris

10

Microbio Tests: Monospot

EBV

11

Microbio Tests: VDRL (Lecitihin/Cardiolipin)

Syphilis/ Treponemal

12

Stains: Congo Red

Amyloidosis
Multiple Myeloma - Bone Marrow
Alzheimer - Brain

13

Stains: Cytokeratin

Alcoholic Hepatitis
Detects Mallory Bodies
Stain intermediate filaments

14

Stains: PAS
Give 4

Gaucher
Niemann-Pick
Alpha-1 ANtutrypsin
Whipple Disease
Stains glycogen, glycoprotein and BMs

15

Stains: Prussian Blue

Hemochromatosis
Stains iron deposition

16

Stains: Trichrome

Fibrosis and cirrhosis

17

Stains: Ziehl-Neelsen

Acid Fast Bacilli

18

Antibodies to Centromeres

CREST

19

Antibodies to GP210

Biliary Cirrhosis

20

Antibodies to SSA ribonucleoprotein (RBP)

Sjogren Syndrome

21

Antibodies to SM

SLE

22

Antibodies to DNA topoisomerase (anti SCL 70)

Diffuse Systemic Sclerosis

23

Antihistone

Drug-induced SLE

24

Patho: Elongated azurophilic Needles with myeloblasts

Auer Rods
AML

25

Patho: epitheloid macrophages with granulomas in thyroid

De Quervain
Subacute Granulomatous Thyroiditis

26

Patho: Laminated, concentric, calcific spherules in thyroid

pasmomma boidees of Papillary CA

27

Patho: Spindle cells and giant cell differentiation in thyroid

Anaplastic CA

28

Patho: Uniform cells forming small follicles containing colloid in thyroid

Follicular CA

29

3p
Chromosome Tumor Suppressor Genes

Von Hippel Lindau Gene
(HIF-1a - Hypoxia Inducible Factor 1 alpha)

30

5q
Chromosome Tumor Suppressor Genes

APC
(FAP)

31

13q
Chromosome Tumor Suppressor Genes

Rb
(Retinoblastoma, Osteosarcoma)

32

17q
Chromosome Tumor Suppressor Genes

NF1
(Cafe Au lait spots, ASTROCYTOMAS)

33

22q
Chromosome Tumor Suppressor Genes

NF 2
(Meningioma, Optic Glioma, BILATERAL SCHWANNOMAS)

34

Microbio Test: cold agglutinins

Mycoplasma pneumoniae

35

Microbio Test: Silver Staining

Legionella

36

Microbio Test: Quellung Reaction

Strep pneumoniae

37

Microbio Test: Requirement for Cysteine

ELLAS
Francisella, Legionella, Brucella, Pasteurella

38

Microbio Test: Requirement for Factor X and V

H influenzae

39

What causes atypical pneumonia? (3)

Mycoplasma, Chlamydia, Legionella

40

Indomethacin will _____ the PDA

CLOSE

41

Alprostadil will _______ the PDA

OPEN

42

CREST

Calcinosis
Reynaud's
Esophageal dysmotility
Sclerodactyly
Telangiectasia

43

Arthritis that is (-) Rheumatoid Factor

HLA-B27

44

What does Reiter SYndrome and Psoriatic Arthritis have in common?

HLA-B27

45

Erythroblastosis fetalis
Mother is positive for ______ Coombs

Indirect

46

Erythroblastosis fetalis
Baby is positive for ________ Coombs

Direct

47

Jaundice, kernicterus
where in brain?

basal ganglia

(thalamus, cerebellum, cerebral gray matter, spinal cord)

48

ChemoTx: Inhibits DNA polymerase; pyrimidine analog

Cytarabine

49

ChemoTx: DNA strand breaks; iron forming ROS

Bleomycin

50

ChemoTx: Pulmonary fibrosis ADR

Bleomycin

51

ChemoTx: DNA strand breaks; inserts in between DNA bases

Doxorubicin

52

ChemoTx: Topoisomerase inhibitor

Etoposide

53

ChemoTx: Inhibits mitosis by binding to tubulin' preventing degradation of microtubules

Paclitaxel

54

ChemoTx: Alopecia and BM Suppression ADR

Paclitaxel

55

Wilson Disease Chellator

Penicillamine

56

MOA of LACTULOSE IN hEPATIC eNCEPHALOPATHY

aCIDIFICATION OF INTESTINAL CONTENTS

57

Oncogenes: MYCC

Burkitt Lymphome

58

Oncogenes: MYCL

Small cell carcinoma

59

Oncogenes: MYCN

Neuroblastoma

60

Oncogenes: RET

MEN 2A / 2B

61

Oncogenes: WT1

Wilm's Tumor

62

Pediatric palpable abdominal mass that crosses midline

Neuroblastoma

63

Pediatric palpabale abdominal mass that does not cross the midline

Wilm's Tumor

64

Where can you find rosettes?
(3) Hint: REMoma

Ependymoma
Retinoblastoma
Medulloblastoma

65

WAGR

Wilm's Tumor
Aniridia
Genitourinary malformations
Retardation

66

Innervates interosseus muscles and opponens

Lower trunk of the brachial plexus

67

innervates interosseus muscles but not opponens

ulnar nerve

68

innervates opponens muscle but not interosseous muscles

median nerve (innervates thenar muscles instead)

69

Gm positive branching rods

Actinomyces

70

Yellow granular pus from absecces around jaw

Actinomyces
Cervicofacial mycetoma

71

Marfanoid habitus + intellectual disability

Homocysteinuria

72

Difference between lens subluxation for Marfan's vs Homocysteinuria

Downward: Homocystenuria
Upward: Marfans

73

Marfanoid habitus + pheochromocytoma, or thyroid/parathyroid problesm

MEN 2A

74

Increased C-peptide, Increased Insulin

Insulinoma

75

Decreased C-peptide, Decreased Insulin

DM Type 1

76

No C-peptide, Increased Insulin

Insulin Injection

77

Keratin-filled cysts

Seborrheic Dermatitis
Mole that can be scraped off

78

Koilocytosis

HPV
Warts

79

Nuclear atypia of basal keratinocytes

Actinic keratosis
Premalignant SCC

80

Palisaded malignant basal cell

Basal Cell CA
grows under the dermis --> pearly grey lesions

81

Abnormal uterine bleeding; uniformly enlarged uterus

Adenomyosis
(Endometrial glandular tissue within the myometrium)

82

Greater increase in endometrial gland proliferation as compared to stroma

endometrial hyperplasia

83

hyperplastic growth of endometrial glands AND stroma

endometrial polyp

84

Na/Cl cotransporter inhibition (in renal tubules)

Thiazide diuretic

85

Diuretic that will cause Hypercalcemia

Thiazide Diuretic

86

Vaccines that will stimulate MHC Class 1 antigen-processing pathway and can generate CD8 + lymphocytes that kill infected cells

Live-attenuated viral vaccines

87

How does FLU vaccine work?
a. Impaired intracellular viral assembly
b. Inhibition of viral genome replication
c. inhibition of viral entry into cells

C
Flu vaccine induces neutralizing antibodies against hemagglutinin antigen of selected strains which will inhibit binding of the hemagglutinin to sialylated receptors on the host cell membrane

88

Turner Syndrome
Genetic Pathophysio?

Meiotic nondisjunction
45X

89

Missing SHOX gene

Turner Syndrome
REason for short stature
SHOX gene promotes long bone growth

90

Klinefelter Syndrome
Genetic Pathophysio?

Meiotic nondisjunction

91

Huntington Disease
_ _ _ repeats

CAG

92

Fragile X syndrome
_ _ _ repeats

CGG

93

Myotonic Dystrophy
_ _ _ repeats

CTG

94

______ psychotherapy

developing insight into unresolved conflicts in childhood

95

_______ psychotherapy

bolstering adaptive psychological defenses to help individuals cope with acute crises or chronic psychiatric illness

96

mid-systolic click

mitral valve prolapse

97

shorter s2-to-opening snap interval

worsening mitral stenosis

98

murmur that can tell severity of mitral REGURGITATION

presence of audible S3

99

Key cell player in formation of abscesses

Neutrophils

100

What causes liquefactive necrosis in the lungs/lung abscess?

Release of cytotoxic granules by lysosomes
e.g. myeloperoxidases