C&P: Local Anaesthetics Flashcards Preview

FRCA Anaesthesia > C&P: Local Anaesthetics > Flashcards

Flashcards in C&P: Local Anaesthetics Deck (47):
1

Ester (-COO-) Local Anaesthetics

Procaine, Amethocaine

2

Amide (-NHCO-) Local Anaesthetics

Lidocaine, Prilocaine, Bupivacaine, Ropivacaine, Mepivacaine

3

pH of Local Anaesthetics

All are weak bases, they have hydrophilic plus hydrophobic components liked by an ester or amide group (hence classification)

4

Local Anaesthetics acting as Vasodilators

prilocaine >lidocaine >bupivacaine >ropivacaine

5

Potency

Related to lipid solubility

6

Speed of onset

Related to pKa

7

Duration of action

Related to protein binding

8

Metabolism of ester local anaesthetics

esterases break down to para-aminobenzoic acid (allergenic)

9

Metabolism of amide local anaesthetics

by hepatic amidases

10

Procaine: Relative Potency

1 (ie itself)

11

Procaine: Onset/Duration

slow onset, short duration

12

Procaine: Maximum dose (mg/kg)

12

13

Procaine: Toxic plasma level (mg/ml)

not in C&P

14

Procaine: pKa

8.9

15

Procaine: Protein bound (%)

6

16

Procaine: Relative lipid solubility

1 (ie itself)

17

Lidocaine: Relative Potency

2

18

Lidocaine: Onset/Duration

fast onset, medium duration

19

Lidocaine: Maximum dose (mg/kg)

3 (7 with adrenaline)

20

Lidocaine: Toxic plasma level (mg/ml)

>5

21

Lidocaine: pKa

7.9

22

Lidocaine: Protein bound (%)

70

23

Lidocaine: Relative lipid solubility

150

24

Lidocaine: Volume of distribution (L)

92

25

Bupivacaine: Relative Potency

8

26

Bupivacaine: Onset/Duration

medium onset, long duration

27

Bupivacaine: Maximum dose (mg/kg)

2

28

Bupivacaine: Toxic plasma level (mg/ml)

>1.5

29

Bupivacaine: pKa

8.1

30

Bupivacaine: Protein bound (%)

95

31

Bupivacaine: Relative lipid solubility

1000

32

Bupivacaine: Volume of distribution (L)

73

33

Ropivacaine: Relative Potency

8

34

Ropivacaine: Onset/Duration

medium onset, long duration

35

Ropivacaine: Maximum dose (mg/kg)

3.5

36

Ropivacaine: Toxic plasma level (mg/ml)

>4

37

Ropivacaine: pKa

8.1

38

Ropivacaine: Protein bound (%)

94

39

Ropivacaine: Relative lipid solubility

300

40

Ropivacaine: Volume of distribution (L)

59

41

Mepivacaine: Relative Potency

2

42

Mepivacaine: Onset/Duration

slow onset, medium duration

43

Mepivacaine: Maximum dose (mg/kg)

5

44

Mepivacaine: Toxic plasma level (mg/ml)

>5

45

Mepivacaine: pKa

7.6

46

Mepivacaine: Protein bound (%)

77

47

Mepivacaine: Relative lipid solubility

50