C&P: Non-depolarizing Muscle Relaxants Flashcards Preview

FRCA Anaesthesia > C&P: Non-depolarizing Muscle Relaxants > Flashcards

Flashcards in C&P: Non-depolarizing Muscle Relaxants Deck (33):
1

Aminosteroid muscle relaxants

Vecuronium, Rocuronium, Pancuronium
All increased duration of action in renal failure

2

Benzylisoquinolinium muscle relaxants

Atracurium, cis-atracurium, Mivacurium, Gallamine, Turbocare

3

Monoquaternary muscle relaxants

Vecuronium, rocuronium
(both aminosteroids)

4

Bisquaternary muscle relaxants

Pancuronium (aminosteroid)

5

Vecuronium: Structure

monoquaternary

6

Vecuronium: Dose (mg/kg)

0.1

7

Vecuronium: Onset/duration

medium onset medium duration

8

Vecuronium: Protein Bound (%)

10

9

Vecuronium: Metabolism/elimination in bile/elimination in urine

Metabolism: 20% (deacetylation)
Elimination in bile: 70%
Elimination in urine: 30%

10

Vecuronium: Effect in renal failure

Prolonged action (all the aminosteroids)

11

Rocuronium: Structure

Monoquaternary

12

Rocuronium: Dose (mg/kg)

0.6 (0.9 RSI)

13

Rocuronium: Onset/duration

rapid onset, medium duraiton

14

Rocuronium: Protein Bound (%)

10

15

Rocuronium: Metabolism/elimination in bile/elimination in urine

Metabolism: <5% (deacetylation)
Elimination in bile: 60%
Elimination in urine: 40%

16

Rocuronium: Effect in renal failure

Prolonged effect

17

Atracurium: Structure

Benzylisoquinolinium
10 stereoisomers

18

Atracurium: Dose (mg/kg)

0.5

19

Atracurium: Onset/duration

medium onset, medium duration

20

Atracurium: Protein Bound (%)

15

21

Atracurium: Metabolism/elimination in bile/elimination in urine

Metabolism: 90% (hoffman degradation and ester hydrolysis)
Elimination in bile: 0%
Elimination in urine: 10%

22

Atracurium: Effect in renal failure

No change

23

Cis-atracurium: Dose (mg/kg)

0.2

24

Cis-atracurium: Onset/duration

medium onset, medium duration

25

Cis-atracurium: Protein Bound (%)

15

26

Cis-atracurium: Metabolism/elimination in bile/elimination in urine

Metabolism: 95%
Elimination in bile: 0%
Elimination in urine: 5%

27

Cis-atracurium: Effect in renal failure

No change

28

Mivatracurium: Structure

Benzylisoquinolinium
3 stereoisomers

29

Mivatracurium: Dose (mg/kg)

0.2

30

Mivatracurium: Onset/duration

medium onset, short duration

31

Mivatracurium: Protein Bound (%)

10

32

Mivatracurium: Metabolism/elimination in bile/elimination in urine

Metabolism: 90% (by plasma cholinesterases)
Elimination in bile: 0%
Elimination in urine: 5%

33

Mivatracurium: Effect in renal failure

No change