C&P: Opioids Flashcards Preview

FRCA Anaesthesia > C&P: Opioids > Flashcards

Flashcards in C&P: Opioids Deck (60):
1

Opioids pH

All bases

2

Morphine: pKa

8.0

3

Morphine: relative lipid solubility

1 (ie relative to itself)

4

Morphine: relative potency

1 (ie relative to itself)

5

Morphine: protein binding (%)

35

6

Morphine: volume of distribution (L/kg)

3.5

7

Morphine: oral bioavailability (%)

25-30

8

Morphine: metabolism

Glucuronidation; N-demethylation

9

Morphine: clearance (ml/(kg*min))

16

10

Morphine: elimination rate (min)

170

11

Diamorphine: chemical composition

Diacetylmorphine

12

Diamorphine: pKa

7.6

13

Diamorphine: relative lipid solubility

250

14

Diamorphine: relative potency

2

15

Diamorphine: protein binding (%)

40

16

Diamorphine: volume of distribution (L/kg)

5

17

Diamorphine: oral bioavailability

low

18

Diamorphine: metabolism

ester hydrolysis to morphine

19

Diamorphine: clearance (ml/(kg*min))

3.1

20

Diamorphine: elimination rate (min)

5 (half life)

21

Codeine: chemical composition

methylmorphine

22

Codeine: pKa

8.2

23

Codeine: relative lipid solubility

n/a

24

Codeine: relative potency

0.1

25

Codeine: protein binding (%)

7

26

Codeine: volume of distribution (L/kg)

5.4

27

Codeine: oral bioavailability (%)

50 (20-80)

28

Codeine: metabolism

Glucuronidation, demethylation (CYP2D6)

29

Codeine: clearance (ml/(kg*min))

23

30

Codeine: elimination rate (min)

170

31

Fentanyl: pKa

8.4

32

Fentanyl: relative lipid solubility

600

33

Fentanyl: relative potency

100

34

Fentanyl: protein binding (%)

83

35

Fentanyl: volume of distribution (L/kg)

4.0

36

Fentanyl: oral bioavailability (%)

33

37

Fentanyl: metabolism

N-Dealkylation then hydroxylation

38

Fentanyl: clearance (ml/(kg*min))

13

39

Fentanyl: elimination rate (min)

190

40

Fentanyl: chemical composition

Synthetic phenylpiperidines

41

Alfentanil: pKa

6.5

42

Alfentanil: relative lipid solubility

90

43

Alfentanil: relative potency

10-20

44

Alfentanil: protein binding (%)

90

45

Alfentanil: volume of distribution (L/kg)

0.6

46

Alfentanil: oral bioavailability (%)

n/a

47

Alfentanil: metabolism

N-Demethylation

48

Alfentanil: clearance (ml/(kg*min))

6

49

Alfentanil: elimination rate (min)

100

50

Alfentanil: chemical composition

Synthetic phenylpiperidines

51

Remifentanil: pKa

7.1

52

Remifentanil: relative lipid solubility

20

53

Remifentanil: relative potency

100

54

Remifentanil: protein binding (%)

70

55

Remifentanil: volume of distribution (L/kg)

0.3

56

Remifentanil: oral bioavailability (%)

n/a

57

Remifentanil: metabolism

Plasma and tissue esterases

58

Remifentanil: clearance (ml/(kg*min))

40

59

Remifentanil: elimination rate (min)

10

60

Remifentanil: chemical composition

Synthetic phenylpiperidines