C15 Lipids & Lipoproteins Flashcards Preview

Clinical Chemistry > C15 Lipids & Lipoproteins > Flashcards

Flashcards in C15 Lipids & Lipoproteins Deck (42):
1

General function of lipoproteins?

provide the transportation system for different types of water insoluble fats

2

What is the #1 cause of premature death in the US?

Coronary Artery Disease

3

What causes inflammation of the coronary edothelial cells?

smoking, hypertension, infection, or other agents that attract monocytes & platelets

4

What are lipoproteins?

group of related, but different molecules that interact w/ water insoluble fat molecules, & transports those fats in the plasma

5

4 types of lipoproteins?

chylomicrons, very low density lipoproteins (VLDL), low density lipoproteins (LDL), & high density lipoproteins (HDL)

6

Transport of dietary triglycerides from GI tract to the liver?

Chylomicrons

7

Tranports triglycerides from liver to tissues for storage and energy?

Very Low Density Lipoproteins (VLDL)

8

Transports cholesterol to peripheral tissues?

Low Density Lipoproteins (LDL)

9

Transports cholesterol away from peripheral tissues and to the liver?

High Density Lipoproteins (HDL)

10

Lipids include:

cholesterol, triglycerides, phospholipids, & glycolipids

11

No double bonds between carbons (C-C), solid at room temp, & animal sources?

Saturated fatty acids, they are fully saturated with hydrogen atoms

12

double bonds between carbon bonds (C=C), usually lipid at room temp, plant sources

unsaturated fatty acids

13

artificial modifications of unsaturated fats, common food additive, not needed & not good for humans

trans fats

14

Triglycerides have glycerol with how many fatty acids attached?

3

15

exogenous source?

dietary

16

endogenous source?

liver and tissue storage

17

what percent of the body fat is triglycerides?

95%

18

what is the energy source when plasma glucose is decreased?

triglycerides

19

Tryglyceride metabolism is regulated by:

lipase, epinephrine, & cortisol

20

Where is cholesterol found?

animals

21

Cholesterol is an important component of?

membranes, steroid hormones, bile & Vitamin D

22

What percentage of cholesterol is associated with cellular components?

70%

23

What percentage of cholesterol is in the plasma?

30%

24

What transports cholesterol?

HDL & LDL

25

Phospholipids

imortant components of cell membranes, (lecithin/sphingomyelin ratio) used to determine fetal lung maturity from amniotic fluid

26

glycolipids

lipids with carbohydrate (ABO antigens...)

27

apoliproproteins

outer protein shell of the lipoprotein molecule, allows insoluble lipid to become soluble in plasma, interacts with cell membranes & enzyme to transport lipids to specific locations

28

chylomicrons & VLDL move?

triglycerides

29

LDL & HDL move?

cholesterol

30

Cholymicrons are removed from the plasma within how many hourse from the liver?

6

31

LDL is synthesized in the?

liver

32

Which cholesterol is bad?

LDL

33

HDL is synthesized in the?

liver & intestines

34

Which cholesterol is good?

HDL

35

What pathway transports dietary lipids, mostly the chylomicrons transportation of triglycerides to the liver?

exogenous pathway

36

What pathway is the transportation of lipids from the liver to the tissues?

endogenous pathway (VLDL & LDL)

37

insulin always decreases?

plasma glucose

38

insulin inactivates?

lipase

39

insulin stimulates?

lipogenesis

40

insulin helps make?

fat

41

What is the specimen collection method for lipid testing?

serum, from a 10-12 hr fasting specimen... failure causes falsely increased levels from recent dietary intake

42

free glycerol is proportional to the initial?

triglyceride concentration