Flashcards in C15 Lipids & Lipoproteins Deck (42):
General function of lipoproteins?
provide the transportation system for different types of water insoluble fats
What is the #1 cause of premature death in the US?
Coronary Artery Disease
What causes inflammation of the coronary edothelial cells?
smoking, hypertension, infection, or other agents that attract monocytes & platelets
What are lipoproteins?
group of related, but different molecules that interact w/ water insoluble fat molecules, & transports those fats in the plasma
4 types of lipoproteins?
chylomicrons, very low density lipoproteins (VLDL), low density lipoproteins (LDL), & high density lipoproteins (HDL)
Transport of dietary triglycerides from GI tract to the liver?
Tranports triglycerides from liver to tissues for storage and energy?
Very Low Density Lipoproteins (VLDL)
Transports cholesterol to peripheral tissues?
Low Density Lipoproteins (LDL)
Transports cholesterol away from peripheral tissues and to the liver?
High Density Lipoproteins (HDL)
cholesterol, triglycerides, phospholipids, & glycolipids
No double bonds between carbons (C-C), solid at room temp, & animal sources?
Saturated fatty acids, they are fully saturated with hydrogen atoms
double bonds between carbon bonds (C=C), usually lipid at room temp, plant sources
unsaturated fatty acids
artificial modifications of unsaturated fats, common food additive, not needed & not good for humans
Triglycerides have glycerol with how many fatty acids attached?
liver and tissue storage
what percent of the body fat is triglycerides?
what is the energy source when plasma glucose is decreased?
Tryglyceride metabolism is regulated by:
lipase, epinephrine, & cortisol
Where is cholesterol found?
Cholesterol is an important component of?
membranes, steroid hormones, bile & Vitamin D
What percentage of cholesterol is associated with cellular components?
What percentage of cholesterol is in the plasma?
What transports cholesterol?
HDL & LDL
imortant components of cell membranes, (lecithin/sphingomyelin ratio) used to determine fetal lung maturity from amniotic fluid
lipids with carbohydrate (ABO antigens...)
outer protein shell of the lipoprotein molecule, allows insoluble lipid to become soluble in plasma, interacts with cell membranes & enzyme to transport lipids to specific locations
chylomicrons & VLDL move?
LDL & HDL move?
Cholymicrons are removed from the plasma within how many hourse from the liver?
LDL is synthesized in the?
Which cholesterol is bad?
HDL is synthesized in the?
liver & intestines
Which cholesterol is good?
What pathway transports dietary lipids, mostly the chylomicrons transportation of triglycerides to the liver?
What pathway is the transportation of lipids from the liver to the tissues?
endogenous pathway (VLDL & LDL)
insulin always decreases?
insulin helps make?
What is the specimen collection method for lipid testing?
serum, from a 10-12 hr fasting specimen... failure causes falsely increased levels from recent dietary intake