Calcium, Phosphate, And Metabolic Bone Disease Flashcards Preview

Clinical Biochemistry > Calcium, Phosphate, And Metabolic Bone Disease > Flashcards

Flashcards in Calcium, Phosphate, And Metabolic Bone Disease Deck (16):
1

What's phosphate metabolism roles?

Phospholipids
Nucleotides- ATP

2

What 3 areas are there of calcium and phosphate?

Gastrointestinal
Kidney
Bone (CaPO4)

3

What percentage of plasma calcium is unfilterable?

53%

4

What percentage is the plasma calcium protein bound?

47%

5

What hormone controls calcium in the para thyroid gland?

Parathormone (PTH)

6

What hormone controls calcium in the kidney?

Calcitrol
1,25 (OH) 2D

7

What hormone controls calcium in the thyroid gland?

Calcitonin

8

What's the 4 step process of calcitriol?

7 dehydrocholestral--->calciferol--->25 (OH) D--->1,25 (OH)2D

9

Key facts on bone?

Dynamic tissue
Opposite action of 2 types of cells (osteoclasts,formation)
(Osteoblasts, remodelling)

10

What are the 2 main proteins in the bone?

Collegen
Calcium phosphate

11

Alkaline phosphate (ALP)

Key enzyme in normal bone physiology

12

Disorders of calcium or phosphate homeostasis

Hypercalciemia
Decreased renal secretion
Increased renal secretion
Increased bone loss

13

Pathophysiology of hypercalcemia?

Neurological symptoms
Muscle weakness
ECG anomalies
Polydipsia

14

Roles of hypercalcemia

Influences nerve action potentials
Alter Na and k channels
Role as a intracellular messenger

15

Biochemical tests for suspected hyperparathyroidism?

Calcium-->elevated
Albumin-->to control
Phosphate-->decreased
ALP-->increased
Total Co2-->if decreased, supports diagnosis
PTH (elevated)

16

What's calcium metabolism roles?

1-influences nerve action potentials
2-alter Na and K channels
3-role as an intracellular messenger