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Flashcards in Cancer Deck (36):
1

Cancer drugs acting on the M phase

Vincristine
Vinblastine
Paclitaxel

2

Cancer drugs acting on the G2 phase

Bleomycin

3

Cancer drugs acting on the S phase

CHEM 66

Cytarabine
Hydroxyurea
Etoposide
Methotrexate
6- mercaptopurine
6- thioguanine

4

Rescue drug for methotrexate

Leucovorin

5

Rescue drug of cyclophosphamide

MESNA

6

Rescue drug for doxorubicin

Dexrazoxane

7

Rescue drug for cisplatin

Amifostine

8

Alkylating agent, cell cycle non specific for non Hodgkin lymphoma

Can cause hemorrhagic cystitis

Cyclophosphamide

9

Cyclophosphamide can cause hemorrhagic cystitis because it forms ____ which can cause direct toxicity to the bladder

Acrolein

10

Platinum based alkylating agent, CCNS, used for testicular, ovarian, advanced colon cancer

Nephrotoxic and can cause acoustic nerve damage

Cisplatin

11

Nephrotoxicity of cisplatin can be minimized by forced hydration and administration of this drug

Mannitol

12

Alkylating agent, CCNS for hodgkin and non hodgkin lymphoma

Procarbazine
Dacarbazine

13

Alkylating agent for CML

Bone marrow sparing

Busulfan

14

Drugs causing pulmonary fibrosis

BBBAN Me

Bleomycin
Busulfan
Bromocriptine
Amiodarone
Nitrofurantoin
Methotrexate

15

Nitrosourea alkylating agent that is used for brain tumors, highly lipophilic that can cause BBB

Carmustine
Lomustine
Bendamustine

16

Methotrexate inhibits what enzyme?

Dihydrofolate reductase

17

Antimetabolite, S Phase specific, DMARD

Used for choriocarcinoma, primary CNS lymphoma, RA, psoriasis, ectopic pregnancy

Methotrexate

18

Purine antimetabolite that inhibits de novo purine nucleotide synthesis

For acute leukemias

6-Mercaptopurine
6-thioguanine

19

Pyrimidine antimetabolite that inhibits thymidylate synthase, causes thymine less death of cells

Colorectal cancer and skin cancer

5-FU

20

Pyrimidine antimetabolite that inhibits ribonucleotide reductase

Used for acute leukemias and CML in blast crisis

Cytarabine

21

Most specific drug for the S phase

Cytarabine

22

Pyrimidine antimetabolite that inhibits ribonucleotide reductase

For pancreatic cancer

Gemtacibine
Capetacibine- prodrug of 5 FU

23

Vinca alkaloid that prevents microtubule assembly can cause cell arrest at metaphase

Acute leukemia, wilms tumor, neuroblastoma

Acts on M phase

Vincristine

24

Vinca alkaloid that prevents microtubule assembly can cause cell arrest at metaphase

Testicular cancer, Kaposi sarcoma

M phase

Vinblastine

25

Inhibits DNA gyrase, S cycle specific

Lung cancer, non Hodgkin lymphoma

Can cause alopecia

Etoposide

26

Taxane, M phase
Interferes with mitotic spindle and prevents microtubule assembly

Used for advanced breast and ovarian CA

Paclitaxel
Docetaxel

27

Anthracycline anti tumor antibiotic, cell cycle non specific

Can cause dilated cardiomyopathy

Doxorubicin

28

Most specific for G2 of cell cycle

Bleomycin

29

Antitumor antibiotic for melanoma and wilms tumor

Actinomycin D

30

Tyrosine kinase inhibitor
CML
GIST

Imatinib

31

Monoclonal antibody against HER2-neu

For metastatic breast cancer
Cardiotoxic

Trastuzumab

32

Monoclonal antibody that inhibits binding of VEGF, which inhibits tumor vascular permeability

For metastatic colon cancer, non small cell lung cancer and renal

Bevacizumab

33

Monoclonal antibody that binds to CD20 in NHL cells

Rituximab

34

Monoclonal antibody that binds to EGFR

Colorectal cancer

Cetuximab

35

Only vitamin that can cure cancer

All trans retinoic acid

36

All trans retinoic acid is used for

Acute promyelocytic leukemia