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Flashcards in Cancer Chemotherapy Deck (50):
1

6 cancer chemotherapy drugs targetimg cells on the S phase: (6)

CHEM-66:
Cytarabine
Hydroxyurea
Etoposide
Methotrexate
6-mercaptourine
6-thioguanine

2

Cancer chemotherapy drug specific for the G2 phase:

Bleomycin

Think: B is the second letter (2 in G2)

3

Cancer chemotherapy drugs specific for the M phase: (3)

VVP:
Vincristine
Vinblastine
Paclitaxel

4

Rescue drug for methotrexate:

Leucovirin

5

Rescue drug for cyclophosphamide:

MESNA

6

Rescue drug for doxorubicin:

Dexrazoxane

7

Rescue drug for cisplatin:

Amifostine

8

Cell cycle non-specific drug used for non-Hodgkin lymphoma and chronic lymphocytic leukemia. Side effect include hemorrhagic cystitis.
Metabolite responsible for hemorrhagic cystitis:_______________

Cyclophosphamide
acrolein

9

A cell-cycle non-specific platinum-based alkylating agent.
Nephrotoxicity is decreased by administering mannitol with forced hydration.

Cisplatin

SimD:
Carboplatin (SE: acoustic nerve damage)
Oxaliplatin (used for advanced colon cancer; SE includes nausea and vomiting)

10

Cell cycle non-specific drug used for Hodgkin and non-Hodgkin lymphoma. Side effects include disulfiram-like reaction.

Procarbazine

11

Cell cycle non-specific drug used for Hodgkin and non-Hodgkin lymphoma. Side effects include phototoxicity and flu-like syndrome.

Dacarbazine

12

Cell cycle non-specific drug used for chronic myelogenous leukemia and is marrow-sparing. Side effects include pulmonary fibrosis.

Busulfan

13

What drugs (not necessarily chemotherapeutic drugs) cause pulmonary fibrosis? (6)

BBBAN Me!
Bleomycin
Busulfan
Bromocriptine
Amiodarone
Nitrofurantoin
Methotrexate

14

Cell cycle non-specific drug used for brain tumors. Side effects include dizziness and ataxia. It is highly lipophilic allowing ease of passage through the blood-brain barrier into the CNS.

Carmustine

SimD: Lomustine, Bendamustine

15

Drug specific for the S phase which inhibits dihydrofolate reductase. Used for choriocarcinoma, primary CNS lymphoma, rheumatoid arthritis, psoriasis, and ectopic pregnancy. Side effects include bone marrow suppression.

Methotrexate

16

Drug specific for the S phase which is used for AML, ALL, and CML. Side effects include hepatotoxicity (cholestasis, jaundice, necrosis). It is inhibited by allopurinol and febuxostat.

6-mercaptopurine

SimD: 6-thioguanine

17

A cell-cycle specific drug which inhibits thymidilate synthase. It causes thymineless death of cells. It is used for colorectal cancer and skin cancer (basal cell cancer, actinic keratosis).
It undergoes significant first pass effect hence administered IV.

5-fluorouracil (IV)

18

An S phase-specific drug which inhibits ribonucleotide reductase with reduced formation of dNTPs. Used for acute leukemias and CML in blast crisis.

Cytarabine

19

An S phase-specific drug which inhibits ribonucleotide reductase with reduced formation of dNTPs. Used for pancreatic cancer.

Gemcitabine

SimD: Capecitabine

20

A drug which prevents microtubule assembly thereby causing cell arrest at metaphase. Used in acute leukemias. Side effects include peripheral neuritis and paralytic ileus (can be treated with ______________)

Vincristine
bethanecol

21

A drug which prevents microtubule assembly thereby causing cell arrest at metaphase. Used in testicular carcinoma and Kaposi sarcoma. Side effects include bone marrow suppression.

Vinblastine

SimD: Vinorelbine

22

Drug which inhibits DNA topoisomerase II (DNA gyrase) and inhibits the mitochondrial electron transport chain. Used for lung cancer and Non-Hodgkin lymphoma.

Etoposide

SimD: Teniposide

23

Drug which inhibits topoisomerase I. Used for small cell lung cancer. Side effects include bone marrow suppression.

Topotecan

24

Drug which inhibits topoisomerase I. Used for metastatic colorectal cancer. Side effects include diarrhea.

Irinotecan

THINK: "I ran to the can (due to diarrhea)".

25

Drug which prevents microtubule disassembly into tubulin monomers. Used for advanced breast and ovarian cancers. Side effects include neutropenia, thrombocytopenia, and peripheral neuropathy.

Paclitaxel

SimD: Docetaxel

26

The most cardiotoxic of all chemotherapeutic drugs.
Cell cycle non-specific. The see for acute leukemias. Side effects include dilated cardiomyopathy.

Doxorubicin

SimD: daunorubicin, idarubicin, epirubicin, mitoxantrone

27

Drug which intercalates with DNA. Specific for G2 phase. Used for testicular cancer. Side effects include pneumonitis and pulmonary fibrosis.

Bleomycin

28

Cell cycle non-specific drug used for melanoma and Wilms tumor.

Actinomycin D a.k.a. Dactinomycin

29

Tyrosine kinase inhibitor used for CML and gastrointestinal stromatolites tumor. Side effects include fluid retention and interactions with drugs that depend or affect the cytochrome P450 system.

Imatinib

30

Monoclonal antibody which used in metastatic breast cancer. It is effective for HER2/neu receptor (+) tumors. Side effects include congestive heart failure.

Trastuzumab

31

Monoclonal antibody which prevent angiogenesis. Used for metastatic colorectal cancer, non-small cell lung cancer, and renal cancer. Side effects include hypertension, arterial thrombosis, impaired wound healing, gastrointestinal perforation, and proteinuria.

Bevacizumab

32

Monoclonal antibody used for low-grade Non-Hodgkin lymphoma.

Rituximab

33

Used for hairy cell leukemia and T-cell lymphomas. Side effects include bone marrow suppression and neurologic dysfunction. Contraindications include autoimmune disease, history of cardiac arrhythmias and pregnancy.

Interferon-alpha

34

Substrate-depleting enzyme used for ALL. Side effects include acute pancreatitis.

Asparaginase

35

The only vitamin that can cure cancer (acute promyelocytic leukemia subtype M2). Side effects include retinoic acid syndrome, which can be treated with __________________.

All-trans retinoic acid
dexamethasone

36

Hormonal anti-cancer agent used for chronic lymphocytic leukemia and Hodgkin lymphoma. Side effects include adrenal suppression.

Prednisone

37

A SERM used for hormone-responsive breast cancer. Side effects include hot flushes, deep gen thrombosis, endometrial hypeeplasia, and endometrial cancer. It prevents osteoporosis and decreases risk of atherosclerosis.

Tamoxifen

SimD: Toremifene

38

Androgen antagonist used for prostate cancer.

Flutamide

SimD:
Bicalutamide
Nilutamide (used for surgical castration)

39

A GnRH analog used for endometriosis, myoma uteri, precocious puberty, and prostate cancer.
It must be co-administered with _____________ to avoid tumor flare-up on imitation of treatment.

Leuprolide
SimD: gonadorelin, nafarelin

flutamide

40

An estrogen synthesis inhibitor which reduces estrogen synth sis by inhibiting aromatase. Used in precocious puberty. Effective against breast cancers that have become resistant to tamoxifen.

Anastrozole

SimD: Letrozole

41

Which chemotherapeutic drug is responsible for the following:
Puffy face

Dexamethasone

42

Which chemotherapeutic drug is responsible for the following:
Acoustic neural damage

Cisplatin, carboplatin

43

Which chemotherapeutic drug is responsible for the following:
Peripheral neuropathy

Vincristine

44

Which chemotherapeutic drug is responsible for the following:
Cardiotoxicity

Doxorubicin

THINK: rubi - red - heart - cardiotoxic

45

Which chemotherapeutic drug is responsible for the following:
Pulmonary fibrosis

Bleomycin

46

Which chemotherapeutic drug is responsible for the following:
Nephrotoxicity

Cisplatin, carboplatin

47

Which chemotherapeutic drug is responsible for the following:
Hemorrhagic cystitis

Cyclophosphamide

48

Which chemotherapeutic drug is responsible for the following:
Myelosuppression

Methotrexate
5-fluorouracil
6-mercaptopurine

49

Main dose-limiting toxicity of vincristine

Neurotoxicity (most commonly peripheral neuropathy)

50

Simultaneous therapy with allopurinol and _____________ would result in increased levels of _____________, leading to excessive toxicity.

Simultaneous therapy with allopurinol and 6-mercaptopurine would result in increased levels of 6-MP, leading to excessive toxicity.

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