Cancer Drugs: the cover-your-ass, bare bones version Flashcards Preview

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Flashcards in Cancer Drugs: the cover-your-ass, bare bones version Deck (36):
0

Mechanism for etoposide

Forms complex between topoisomerase II and DNA

2

Mechanism for busulfan

alkylates DNA

3

Toxicity for busulfan

pulmonary fibrosis

4

Mechanism for bleomycin

fragments DNA

5

Toxicity for bleomycin

pulmonary fibrosis

6

Mechanism for 6-mercaptopurine

blocks purine synthesis

7

Metabolism of 6-mercaptopurine is accomplished by:

xanthine oxidase

8

Mechanism for cisplatin and carboplatin

cross-links DNA

9

Toxicity for cisplatin, carboplatin (2)

nephrotoxic, ototoxic

10

Mechanism for cyclophosphamide

Nitrogen mustard, alkylates DNA (electrophile that binds DNA)

11

Mechanism for methotrexate

Folic acid analog, inhibits dihydrofolate reductase

12

Mechanism for paclutaxol

Prevents tubulin disassembly

13

Mechanism for doxyrubicin and danirubicin

Intercalates DNA, produces oxygen free radicals

14

Toxicity for doxyrubicin and danirubicin

cardiotoxic

15

Mechanism for nitrosureas

DNA alkylating agents, used in brain cancer

16

Mechanism for vincristine and vinblastine

Prevents tubulin assembly

17

Mechanism for 5-fluorouracil

Inhibits thymidylate synthase, leads to decreased nucleotide synthesis

18

Mechanism for tomaxafen/rumoxifen

SERM: blocks estrogen binding to ER+ cells

19

Mechanism for cytaravine (similar to...)

Inhibition of DNA polymerase: similar to acyclovir and foscarnet

20

Mechanism for etoposide (similar to...)

Inhibition of topoisomerase II: similar to fluoroquinolones

21

Mechanism for methotrexate (similar to...)

Folic acid analog, inhibits dihydrofolate reductase: similar to trimethoprim

22

Mechanism for trastuzimab

Monoclonal antibody against HER-2

23

Mechanism for bleomycin, oxyrubicin, danirubicin

Free radical induced DNA strand breakage

24

Mechanism of 6-mercaptopurine

Inhibitor of PRPP synthetase

25

Methotrexate: reversible by...

Leucovorin

26

3 treatments for choriocarcinoma

methotrexate, vincristine, vinblastine

27

Treatment for AML

cytarabine

28

2 treatments for CML

Busulfan, amatanib

29

Prevents breast cancer (2)

Tamoxifen, raloxifene

30

3 treatments for testicular cancer

etoposide, bleomycin, cisplatin

31

Topical treatment for AKs and basal cell cancers

5-fluorouracil

32

Dactinomycin: use

childhood tumors (Ewing's sarcoma, Wilm's tumor, rhabdomyosarcoma)

33

Mechanism of hydroxyurea

Inhibits ribonucleotide reductase

34

Drug with side effect of hemorrhagic cystitis

cyclophosphamide

35

Mechanism for imatinib

Antibody against Philadelphia chromosome

36

Know 9 side effects of Prednisone

Cushing-like symptoms
Immunosuppression
Cataracts
Acne
Osteoporosis
Hypertension
Peptic ulcers
hyperglycemia
Psychosis