Cancer Genes Flashcards Preview

Unit 1: Neoplasia > Cancer Genes > Flashcards

Flashcards in Cancer Genes Deck (35):
1

c-ret point mutation (2)

MEN (multiple endocrine neoplasm) type 2: thyroid and adrenals

2

bcr-abl t(9,22) translocation

CML

3

c-met point mutation

papillary renal cancer

4

c-myc t(8,14) translocation

Burkitt lymphoma

5

c-sis overexpression

astrocytoma

6

HST GOF

Kaposi sarcoma

7

erbb2 amplification (3)

breast, ovarian, and lung cancers

8

c-tel GOF

myelomonocytic leukemia

9

n-myc amplification

neuroblastoma

10

l-myc GOF

small cell lung cancer

11

Ki-ras point mutation (3)

colon, pancreas, and lung cancers

12

c-kit GOF

GISTs, GI stromal tumors

13

Rb LOF (2)

retinoblastoma, osteosarcoma

14

BRCA 1 and 2 LOF, impaired DNA double strand break repair (2)

breast and ovarian cancer

15

p16 / CDKN2 deletion or methylation

Familial melanoma

16

p53 LOF (4)

Li-Fraumeni: multiple cancers including breast, soft tissue, leukemia, brain

17

WT1 LOF

Wilm's tumor, childhood kidney cancer

18

NF1 deletion

Neurofibromatosis type 1: CNS glioma

19

APC inactivation

polyps and colon cancer

20

VHL GOF

Von Hippel-Lindau Syndrome: kidney and others

21

FHIT GOF

Fragile HIstidine Triad: multiple tumors

22

PTEN LOF (3)

Cowden / Multiple Hamartoma Syndrome: breast, thyroid, colon, etc.

23

BLM inactivation

Bloom Syndrome: many cancer sites, sunlight sensitivity

24

MEN1

MEN (multiple endocrine neoplasia) type 1: pancreas

25

NF2 LOF

Neurofibromatosis type 2: Schwannomas

26

hMSH2 loss of DNA mismatch repair

HNPCC / Lynch Syndrome: colon, melanoma, endometrium

27

TSC1

Tuberous sclerosis: kidney

28

bcl-2 t(14,18) translocation

Follicular lymphoma

29

ATM (2)

Ataxia-telangiectasia: lymphoma and leukemia

30

XP group, defect in nucleotide excision repair (2)

Xenoderma pigmentosum: squamous cell carcinoma and melanoma

31

EGFR / HER1 amplification (3)

lung cancer, breast cancer, gliobastoma

32

PRAD1 / Cyclin D1 (CCND1) amplification (3)

breast cancer, esophageal cancer, lymphoma

33

Myb amplification

leukemia

34

MLH1

Lynch Syndrome: colon

35

bcl-1 t(11,14) translocation

Mantle cell lymphoma