Cancer/Immunotherapy Flashcards Preview

People and Illness > Cancer/Immunotherapy > Flashcards

Flashcards in Cancer/Immunotherapy Deck (12)
Loading flashcards...
1
Q

What is cancer immunoediting?

A

Cancer immunoediting is a process driven by tumour antigenicity resulting in either: elimination (tumour rejection), equilibrium (immune control of residual tumour cell outgrowth) or escape (tumour evasion of immune control).

2
Q

What is the elimination phase of immunoediting?

A

Both the innate and the adaptive immune systems work together to detect and destroy early tumours before they become clinically visible.

3
Q

What is the equilibrium phase of immunoediting?

A

The immune system holds the tumour in a state of functional dormancy.

4
Q

What is the escape phase of immunoediting?

A

The immune system fails to restrict tumour outgrowth and tumour cells emerge causing clinically apparent disease.

5
Q

What is invasion?

A

Growth by infiltration and destruction of surrounding tissues.

6
Q

What is metastasis?

A

Spread of tumour to-and growth at- ectopic sites, via blood, lymphatics, intra-epithelial route or transcoelomic. Metastatic spread of the primary tumour accounts for over 90% of patient mortality associated with solid cancers.

7
Q

What is carcinoma?

A

Malignant tumour derived from epithelial cells. Approx. 80% of human cancers.

8
Q

What is sarcoma?

A

Malignant tumour derived from mesenchymal cells.

9
Q

What is melanoma?

A

Malignant tumour derived from neural crest cells.

10
Q

What is leukaemia?

A

Malignant tumour derived from circulating white blood cells.

11
Q

What is lymphoma?

A

Malignant tumour derived from the lymphatic system.

12
Q

What is the basement membrane?

A

Is a barrier to cancer spread. It is a layer of ECM made up of fibronectin, type IV collagen, laminin etc.