Cancer syndrome to consider based on indication Flashcards Preview

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Flashcards in Cancer syndrome to consider based on indication Deck (78):
1

>5 cumulative basal cell carcinomas (BCCs) or BCC dx at age 30 or under

Nevoid basal cell carcinoma syndrome (NBCCS) (Gorlin Syndrome)

2

Brain tumor dx before 18

Mismatch repair cancer syndrome (CMMRD)

3

Brain tumor and two additional cases of any LS-associated cancer in the same person or in relatives

Lynch Syndrome (LS)

4

Brain tumor and one additional tumor in the same person or in two relatives, one dx 45 or under

Li Fraumeni syndrome (tumor should be a LFS-associated tumor)

5

Astrocytoma and melanoma in the same person or in two first-degree relatives

Melanoma-Astrocytoma Syndrome (MAS)

6

Subependymal giant cell astrocytoma and one additional criteria in the same person

Tuberous Sclerosis Complex

7

Medulloblastoma and >10 cumulative adenomatous colon polyps in the same person

FAP

8

Medulloblastoma (PNET) dx at age 18 or under

Nevoid basal cell carcinoma syndrome (NBCCS) (Gorlin Syndrome)

9

Breast cancer dx at 35 or younger

HBOC or Li-Fraumeni

10

Triple-negative breast cancer dx at 60 or younger

HBOC

11

2+ primary breast cancers in the same person

HBOC

12

AJ ancestry and breast cancer at any age

HBOC

13

3 or more cases of breast, ovarian, pancreatic, and/or aggressive prostate cancer in close relatives, inclinding the patient

HBOC

14

Breast cancer and one additional LFS tumor in the same person or in two relatives, one dx at age 45 or younger

Li-Fraumeni Syndrome

15

Breast cancer and 1+ PJ polyp in the same person

Peutz-Jeghers Syndrome (PJS)

16

Lobular breast cancer and diffuse gastric cancer in the same person

Hereditary diffuse gastric cancer (HDGC)

17

Lobular breast cancer in one relative and diffuse gastric cancer in another, one dx at age 50 or under

Hereditary diffuse gastric cancer (HDGC)

18

Breast cancer and 2 additional criteria (ex. macrocephaly, LDD tumor)

Cowden syndrome

19

Male breast cancer

HBOC

20

Colorectal cancer dx before 50 years of age

Lynch-Syndrome (LS), Mismatch repair cancer syndrome (CMMRD), MUTYH-associated polyposis (MAP)

21

Colorectal cancer dx 50+ with an first-degree relative with colorectal or endometrial cancer at any age

Lynch-Syndrome (LS), Mismatch repair cancer syndrome (CMMRD), MUTYH-associated polyposis (MAP)

22

Synchronous or metachronous colorectal or endometrial cancers in the same person

Lynch-Syndrome (LS), Mismatch repair cancer syndrome (CMMRD), MUTYH-associated polyposis (MAP)

23

Colorectal cancer showing mismatch repair deficiency on tumor screening

Lynch-Syndrome (LS) or Mismatch repair cancer syndrome (CMMRD)

24

Colorectal cancer and two additional cases of any LS-associated cancer in the same person or in close relatives

Lynch-Syndrome (LS), Mismatch repair cancer syndrome (CMMRD)

25

Colorectal cancer and two additional criteria (ex. macrocephaly, LDD tumor)

Cowden Syndrome (criteria = cowden syndrome criteria)

26

Colorectal cancer and one additional tumor in the same person or in two relatives, one dx at 45 or younger

Lynch Syndrome

27

Colorectal cancer with 10+ cumulative adenomatous colon polyps in the same person

FAP, AFAP, MUTYH-associated polyposis (MAP)

28

10+ cumulative adenomatous colon polyps in the same person

FAP, MAP, AFAP

29

3-5 cumulative histologically proven juvenile polyps in the same person

Juvenile-polyposis syndrome (JPS)

30

Any number of juvenile polyps with a positive family hx

Juvenile-polyposis syndrome (JPS)

31

Multiple juvenile polyps throughout the GI tract in the same person

Juvenile-polyposis syndrome (JPS)

32

One PJ polyp and mucocutaneous hyperpigmentation in the same person

Peutz-Jeghers Syndrome (PJS)

33

GI hamartoma or ganglioneuroma and two additional critera

Cowden Syndrome

34

Rectal hamartomatous polyps and one additional criterion

Tuberous Sclerosis Complex

35

Diffuse ganglioneuromatosis of the GI tract

MEN2

36

5+ serrated polyps proximal to the sigmoid colon, two of which are >1 cm in diameter, in the same person

Serrated Polyposis Syndrome (SPS)

37

20+ serrated polyps at any site in the large bowel in the same person

Serrated Polyposis Syndrome (SPS)

38

Any number of SPs proximal to the sigmoid colon and a positive family history

Serrated Polyposis Syndrome (SPS)

39

10+ cumulative polyps with >1 histology in the same person

Hereditary Mixed Polyposis Syndrome (HMPS)

40

Endometrial cancer diagnosed at younger than 50 years of age

Lynch Syndrome

41

Endometrial cancer dx at age 50+ with a first degree relative with colorectal or endometrial cancer at any age

Lynch Syndrome

42

Synchronous or metachronous colorectal or endometrial cancer

Lynch Syndrome

43

Endometrial cancer showing mismatch repair deficiency on tumor screening

Lynch Syndrome

44

Epithelial endometrial cancer and macrocephaly

Cowden Syndrome

45

2 or more cases of gastric cancer, one dx younger than 50 years of age

Hereditary diffuse gastric cancer (HDGC)

46

3 or more cases of gastric cancer in close relatives

Hereditary diffuse gastric cancer (HDGC)

47

Diffuse gastric cancer at younger than 40 years of age

Hereditary diffuse gastric cancer (HDGC)

48

Diffuse gastric cancer and lobular breast cancer in the same person

Hereditary diffuse gastric cancer (HDGC)

49

Diffuse gastric cancer in one relative and lobular breast cancer in another, one dx before 50 years of age

Hereditary diffuse gastric cancer (HDGC)

50

Gastric cancer and 2 additional cases of any LS-associated cancer in the same person or in close relatives

Lynch Syndrome

51

Leukemia dx before 18 years of age plus cafe-au-lait macules and/or other signs of NF1, or hypopigmented skin lesions, or consaguineous parents, or family history of LS-associated cancers, second primary cancer, sibling with a childhood cancer

Mismatch repair cancer syndrome (CMMRD)

52

Leukemia and one additional tumor in the same person or in 2 close relatives, one dx at 45 years or younger

Li-Fraumeni Syndrome (tumor should be a LFS criteria one)

53

3+ cases of melanoma and/or pancreatic cancer in close relatives

Hereditary Melanoma (HM)

54

3 or more primary melanomas in the same person

Hereditary Melanoma (HM)

55

Melanoma and pancreatic cancer in the same person

Hereditary Melanoma (HM)

56

Melanoma and astrocytoma in the same person or in 2 first-degree relatives

Hereditary Melanoma (HM) or Melanoma-Astrocytoma Syndrome (MAS)

57

Ovarian/Fallopian tube/Primary peritoneal cancer

HBOC, Lynch Syndrome

58

Pancreatic cancer dx at any age, if any of the following criteria are met: - 2+ cases of pancreas cancer in close relatives - 2+ cases of breast, ovarian, and/or aggressive prostate cancer in close relatives - AJ ancestry

HBOC, Familial Pancreatic Cancer

59

Pancreatic cancer and 1 or more PJ polyp in the same person

Peutz-Jeghers Syndrome (PJS)

60

Pancreatic cancer and two additional cases of any Lynch-associated cancer in the same person or in close relatives

Lynch Syndrome

61

3+ cases of pancreatic cancer and/or melanoma in close relatives

Hereditary Melanoma (OMIM 155600)

62

2+ cases of prostate cancer at age 55 or younger in close relatives

Familial Prostate Cancer (FP)

63

3 or more first degree relatives with prostate cancer

Familial Prostate Cancer (FP)

64

Aggressive (Gleason score >7) prostate cancer and 2+ cases of breast, ovarian, and/or pancreas cancer in close relatives

HBOC

65

Renal cell carcinoma (RCC) with clear cell histology, if any of the following criteria are met: diagnosed before age 50, bilateral or multifocal tumors, 1 close relative with clear cell RCC

von-Hippel Lindau (VHL), Birt-Hogg-Dube (BHD)

66

RCC with papillary type 1 histology

Hereditary papillary renal cancer (HPRC)

67

RCC with papillary type 2 histology

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC)

68

RCC with collecting duct histology

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC)

69

RCC with tubulopapillary histology

Hereditary leiomyomatosis and renal cell carcinoma (HLRCC)

70

RCC with crhomophobe, oncocytoma, or oncocytic hybrid

Birt-Hogg-Dube (BHD)

71

Urothelial carcinoma (or transitional cell carcinoma) and 2 additional cases of cancer in the same person or in relatives

Lynch Syndrome

72

RCC and macrocephaly

Cowden Syndrome

73

Angiomyolipomas of the kidney and one addtional criteria

Tuberous Sclerosis complex

74

Medullary Thyroid Cancer

MEN2

75

Nonmedullary thyroid cancer and one additional criteria

Carney

76

Nonmedullary thyroid cancer and 2 additional criteria

Cowden

77

Papillary thyroid cancer (cribriform-morular variant)

FAP

78

Colorectal adenocarcinoma

Lynch Syndrome associated tumor